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Details on Person UniProt:Q12974-4 PTP4A2

Class:IdReferenceIsoform:8969485
_chainChangeLogchain:1-164 added on Fri February 17 2017;propeptide:165-167 added on Fri February 17 2017
_displayNameUniProt:Q12974-4 PTP4A2
_timestamp2025-02-21 20:15:35
chainchain:1-164
propeptide:165-167
checksumE97B88BF87B87943
commentFUNCTION Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateACTIVITY REGULATION Inhibited by sodium orthovanadate and pentamidine.SUBUNIT In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.INTERACTION Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.PTM Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.MISCELLANEOUS A processed pseudogene with 96% sequence identity was found in the BRCA1 (113705) region of 17q21.SIMILARITY Belongs to the protein-tyrosine phosphatase family.
created[InstanceEdit:8964659] Weiser, JD
descriptionrecommendedName: Protein tyrosine phosphatase type IVA 2 ecNumber: 3.1.3.48 alternativeName: HU-PP-1 alternativeName: OV-1 alternativeName: PTP(CAAXII) alternativeName: Protein-tyrosine phosphatase 4a2 alternativeName: Protein-tyrosine phosphatase of regenerating liver 2 shortName: PRL-2
geneNamePTP4A2
PRL2
PTPCAAX2
BM-008
identifierQ12974
isoformParent
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Cell membrane
Cytoplasm
Disulfide bond
Endosome
Hydrolase
Lipoprotein
Membrane
Methylation
Prenylation
Protein phosphatase
Proteomics identification
Reference proteome
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
namePTP4A2
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8999822] ENSEMBL:ENSG00000184007 PTP4A2 [Homo sapiens]
secondaryIdentifierTP4A2_HUMAN
A8K9I8
B4DM39
D3DPP0
E9PGJ6
O00649
Q15197
Q15259
Q15260
Q15261
R4GN50
sequenceLength167
species[Species:48887] Homo sapiens
variantIdentifierQ12974-4
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