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Details on Person UniProt:P51685-2 CCR8
| Class:Id | ReferenceIsoform:8968699 |
|---|---|
| _chainChangeLog | chain:1-355 added on Fri February 17 2017 |
| _displayName | UniProt:P51685-2 CCR8 |
| _timestamp | 2026-02-20 21:37:53 |
| chain | chain:1-355 |
| checksum | BC14A153CF695361 |
| comment | FUNCTION G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed:23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed:35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity).FUNCTION (Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses.FUNCTION (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells.SUBUNIT Interacts with GNAI1.SUBUNIT (Microbial infection) Interacts with Kaposi virus proteins vCCL1 and vCCL2.SUBCELLULAR LOCATION Expressed in unstimulated CD4(+) and CD8(+) T-cells and polymorphonuclear cells.SIMILARITY Belongs to the G-protein coupled receptor 1 family.CAUTION Was originally thought to be a receptor for SCYA3 and SCYA17.ONLINE INFORMATION CC chemokine receptors entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: C-C chemokine receptor type 8 shortName: C-C CKR-8 shortName: CC-CKR-8 shortName: CCR-8 alternativeName: CC chemokine receptor CHEMR1 alternativeName: CMKBRL2 alternativeName: Chemokine receptor-like 1 shortName: CKR-L1 alternativeName: GPR-CY6 shortName: GPRCY6 alternativeName: TER1 cdAntigenNameCDw198/cdAntigenName |
| geneName | CCR8 CKRL1 CMKBR8 CMKBRL2 |
| identifier | P51685 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CCR8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003426] ENSEMBL:ENSG00000179934 CCR8 [Homo sapiens] |
| secondaryIdentifier | CCR8_HUMAN B2RC64 Q3KNQ8 Q3KNR3 Q9BYX5 |
| sequenceLength | 355 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P51685-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P51685-2 CCR8 (8968699)
