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Details on Person UniProt:P04275-2 VWF
| Class:Id | ReferenceIsoform:8968618 |
|---|---|
| _chainChangeLog | signal peptide:1-22 added on Fri February 17 2017;chain:23-763 added on Fri February 17 2017;chain:764-2813 added on Fri February 17 2017 |
| _displayName | UniProt:P04275-2 VWF |
| _timestamp | 2024-11-03 19:39:36 |
| chain | signal peptide:1-22 chain:23-763 chain:764-2813 |
| checksum | D5C1C78360917C29 |
| comment | FUNCTION Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.SUBUNIT Multimeric. Interacts with F8.INTERACTION Localized to storage granules.ALTERNATIVE PRODUCTS Plasma.DOMAIN The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.PTM All cysteine residues are involved in intrachain or interchain disulfide bonds.PTM N- and O-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin in the N-terminal part.ONLINE INFORMATION von Willebrand factor (vWF) mutation dbONLINE INFORMATION Von Willebrand factor entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: von Willebrand factor shortName: vWF component recommendedName: von Willebrand antigen 2 alternativeName: von Willebrand antigen II /component |
| geneName | VWF F8VWF |
| identifier | P04275 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Blood coagulation Cell adhesion Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Hemostasis Proteomics identification Reference proteome Repeat Secreted Signal von Willebrand disease |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | VWF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957777] ENSEMBL:ENSG00000110799 VWF [Homo sapiens] |
| secondaryIdentifier | VWF_HUMAN Q8TCE8 Q99806 |
| sequenceLength | 2813 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P04275-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P04275-2 VWF (8968618)
