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Details on Person UniProt:Q6AZZ1-1 TRIM68
| Class:Id | ReferenceIsoform:8968591 |
|---|---|
| _chainChangeLog | chain:1-485 added on Fri February 17 2017 |
| _displayName | UniProt:Q6AZZ1-1 TRIM68 |
| _timestamp | 2024-11-03 19:59:05 |
| chain | chain:1-485 |
| checksum | FCB9A6076382E2A5 |
| comment | FUNCTION Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.INTERACTION Colocalized with AR in nucleus.ALTERNATIVE PRODUCTS Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.INDUCTION Up-regulated in prostate cancer.DOMAIN The RING domain is essential for ubiquitin E3 ligase activity.PTM Auto-ubiquitinated.MISCELLANEOUS Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.SIMILARITY Belongs to the TRIM/RBCC family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: E3 ubiquitin-protein ligase TRIM68 ecNumber: 2.3.2.27 alternativeName: RING finger protein 137 alternativeName: fullName evidence="9"RING-type E3 ubiquitin transferase TRIM68 alternativeName: SSA protein SS-56 shortName: SS-56 alternativeName: Tripartite motif-containing protein 68 |
| geneName | TRIM68 GC109 RNF137 SS56 |
| identifier | Q6AZZ1 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Metal-binding Nucleus Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TRIM68 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989288] ENSEMBL:ENSG00000167333 TRIM68 [Homo sapiens] |
| secondaryIdentifier | TRI68_HUMAN A6NI19 A8K551 B3KPM5 B4DVK4 Q8WZ70 Q96LE5 Q96PF7 Q9H9C2 Q9NW18 |
| sequenceLength | 485 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q6AZZ1-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6AZZ1-1 TRIM68 (8968591)
