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Details on Person UniProt:P14635-2 CCNB1
| Class:Id | ReferenceIsoform:8967791 |
|---|---|
| _chainChangeLog | chain:1-433 added on Fri February 17 2017 |
| _displayName | UniProt:P14635-2 CCNB1 |
| _timestamp | 2024-11-03 20:09:12 |
| chain | chain:1-433 |
| checksum | E2C4767AE8A11EC0 |
| comment | FUNCTION Essential for the control of the cell cycle at the G2/M (mitosis) transition.SUBUNIT Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187).INTERACTION Accumulates steadily during G2 and is abruptly destroyed at mitosis.PTM Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811).PTM Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: G2/mitotic-specific cyclin-B1 |
| geneName | CCNB1 CCNB |
| identifier | P14635 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Cyclin Cytoplasm Cytoskeleton Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCNB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:4088290] ENSEMBL:ENSG00000134057 CCNB1 [Homo sapiens] |
| secondaryIdentifier | CCNB1_HUMAN A8K066 Q5TZP9 |
| sequenceLength | 433 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P14635-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P14635-2 CCNB1 (8967791)
