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Details on Person UniProt:P06753-6 TPM3
| Class:Id | ReferenceIsoform:8967684 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-285 added on Fri February 17 2017;initiator methionine: for 8967684 added on Sun February 16 2020;initiator methionine: for 8967684 added on Sun February 16 2020;initiator methionine:1 for 8967684 removed on Fri Nov 03 2023;initiator methionine: for 8967684 removed on Fri Aug 15 2025;initiator methionine: for 8967684 removed on Fri Aug 15 2025;initiator methionine: for 8967684 removed on Fri Aug 15 2025;initiator methionine:1 for 8967684 added on Fri Aug 15 2025;initiator methionine:1 for 8967684 added on Fri Aug 15 2025;initiator methionine:1 for 8967684 added on Fri Aug 15 2025 |
| _displayName | UniProt:P06753-6 TPM3 |
| _timestamp | 2025-08-15 21:34:47 |
| chain | initiator methionine:1 chain:2-285 initiator methionine:1 initiator methionine:1 |
| checksum | 99EAD24C45460A14 |
| comment | FUNCTION Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.SUBUNIT Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with TMOD1 (PubMed:8002995). Interacts with TNNT1 (PubMed:35510366).INTERACTION Additional isoforms seem to exist.DOMAIN The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.MISCELLANEOUS Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS. PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.MISCELLANEOUS Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.SIMILARITY Belongs to the tropomyosin family.CAUTION It is uncertain whether Met-1 or Met-2 is the initiator. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Tropomyosin alpha-3 chain alternativeName: Gamma-tropomyosin alternativeName: Tropomyosin-3 alternativeName: Tropomyosin-5 shortName: hTM5 |
| geneName | TPM3 |
| identifier | P06753 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing Chromosomal rearrangement Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Muscle protein Nemaline myopathy Phosphoprotein Proteomics identification Proto-oncogene Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TPM3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961049] ENSEMBL:ENSG00000143549 TPM3 [Homo sapiens] |
| secondaryIdentifier | TPM3_HUMAN D3DV71 P12324 Q2QD06 Q5VU58 Q5VU63 Q5VU66 Q5VU71 Q5VU72 Q8TCG3 Q969Q2 Q9NQH8 |
| sequenceLength | 285 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P06753-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P06753-6 TPM3 (8967684)
