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Details on Person UniProt:O14807-2 MRAS
| Class:Id | ReferenceIsoform:8967588 |
|---|---|
| _chainChangeLog | chain:1-205 added on Fri February 17 2017;propeptide:206-208 added on Fri February 17 2017 |
| _displayName | UniProt:O14807-2 MRAS |
| _timestamp | 2026-02-20 22:15:03 |
| chain | chain:1-205 propeptide:206-208 |
| checksum | 0B2B55AFA96B3EC4 |
| comment | FUNCTION Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Binds 1 magnesium ion per subunit.SUBUNIT Component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (either PPP1CA, PPP1CB or PPP1CC) (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex; SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Interacts with RGL3 (By similarity). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).INTERACTION Expression highly restricted to the brain and heart.INDUCTION By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the small GTPase superfamily. Ras family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Ras-related protein M-Ras ecNumber evidence="3"3.6.5.2 alternativeName: Ras-related protein R-Ras3 |
| geneName | MRAS RRAS3 |
| identifier | O14807 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disease variant GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MRAS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999113] ENSEMBL:ENSG00000158186 MRAS [Homo sapiens] |
| secondaryIdentifier | RASM_HUMAN B4DIK0 Q86WX8 |
| sequenceLength | 208 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O14807-2 |
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No pathways have been reviewed or authored by UniProt:O14807-2 MRAS (8967588)
