Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O14807-1 MRAS
| Class:Id | ReferenceIsoform:8967587 |
|---|---|
| _chainChangeLog | chain:1-205 added on Fri February 17 2017;propeptide:206-208 added on Fri February 17 2017 |
| _displayName | UniProt:O14807-1 MRAS |
| _timestamp | 2026-02-20 22:15:03 |
| chain | chain:1-205 propeptide:206-208 |
| checksum | 0B2B55AFA96B3EC4 |
| comment | FUNCTION Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Binds 1 magnesium ion per subunit.SUBUNIT Component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (either PPP1CA, PPP1CB or PPP1CC) (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex; SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Interacts with RGL3 (By similarity). Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).INTERACTION Expression highly restricted to the brain and heart.INDUCTION By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the small GTPase superfamily. Ras family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Ras-related protein M-Ras ecNumber evidence="3"3.6.5.2 alternativeName: Ras-related protein R-Ras3 |
| geneName | MRAS RRAS3 |
| identifier | O14807 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disease variant GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MRAS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999113] ENSEMBL:ENSG00000158186 MRAS [Homo sapiens] |
| secondaryIdentifier | RASM_HUMAN B4DIK0 Q86WX8 |
| sequenceLength | 208 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O14807-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14807-1 MRAS (8967587)
