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Details on Person UniProt:Q9HC35-1 EML4
| Class:Id | ReferenceIsoform:8967390 |
|---|---|
| _chainChangeLog | chain:1-981 added on Fri February 17 2017 |
| _displayName | UniProt:Q9HC35-1 EML4 |
| _timestamp | 2024-11-03 19:45:35 |
| chain | chain:1-981 |
| checksum | 7E8F2585747736B9 |
| comment | FUNCTION Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526).SUBUNIT Homotrimer; self-association is mediated by the N-terminal coiled coil (PubMed:25740311). Interacts (via WD repeats) with NUDC (PubMed:25789526). Interacts with alpha- and beta-tubulin during mitosis (PubMed:31409757).SUBCELLULAR LOCATION Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis.ALTERNATIVE PRODUCTS Phosphorylated during mitosis (PubMed:16890222). Phosphorylation at Ser-144 and Ser-146 promotes its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757).DISEASE A chromosomal aberration involving EML4 has been identified in a subset of patients with non-small-cell lung carcinoma. This aberration leads to the production of a fusion protein between the N-terminus of EML4 and the C-terminus of ALK. It is unclear whether the fusion protein is caused by a simple inversion within 2p (inv(2)(p21p23)) or whether the chromosome translocation involving 2p is more complex. When tested in a heterologous system, the fusion protein EML4-ALK possesses transforming activity that is dependent on ALK catalytic activity, possibly due to spontaneous dimerization mediated by the EML4 moiety, leading to ALK kinase activation.SIMILARITY Belongs to the WD repeat EMAP family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Echinoderm microtubule-associated protein-like 4 shortName: EMAP-4 alternativeName: Restrictedly overexpressed proliferation-associated protein alternativeName: Ropp 120 |
| geneName | EML4 C2orf2 EMAPL4 |
| identifier | Q9HC35 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Chromosomal rearrangement Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Microtubule Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | EML4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998283] ENSEMBL:ENSG00000143924 EML4 [Homo sapiens] |
| secondaryIdentifier | EMAL4_HUMAN A6H8Y6 A6P4T4 A6P4V4 B2RBK3 B2RTW7 B5MCW9 Q3SWW0 Q53R29 Q53TW8 Q6PJ45 Q9NV40 |
| sequenceLength | 981 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9HC35-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HC35-1 EML4 (8967390)
