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Details on Person UniProt:Q99966-1 CITED1
| Class:Id | ReferenceIsoform:8967342 |
|---|---|
| _chainChangeLog | chain:1-193 added on Fri February 17 2017 |
| _displayName | UniProt:Q99966-1 CITED1 |
| _timestamp | 2024-11-03 19:45:06 |
| chain | chain:1-193 |
| checksum | 9B0CF50CA639ECCB |
| comment | FUNCTION Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.SUBUNIT Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.INTERACTION Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.ALTERNATIVE PRODUCTS Expressed only in melanocytes and testis.INDUCTION Up-regulated by GPR39 in neuronal cells.PTM Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.SIMILARITY Belongs to the CITED family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Cbp/p300-interacting transactivator 1 alternativeName: Melanocyte-specific protein 1 |
| geneName | CITED1 MSG1 |
| identifier | Q99966 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing Apoptosis Cytoplasm Developmental protein Differentiation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CITED1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990029] ENSEMBL:ENSG00000125931 CITED1 [Homo sapiens] |
| secondaryIdentifier | CITE1_HUMAN B5BU50 B5BUI2 |
| sequenceLength | 193 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q99966-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99966-1 CITED1 (8967342)
