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Details on Person UniProt:Q03167-2 TGFBR3
| Class:Id | ReferenceIsoform:8967226 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 17 2017;chain:21-851 added on Fri February 17 2017 |
| _displayName | UniProt:Q03167-2 TGFBR3 |
| _timestamp | 2025-02-21 18:42:49 |
| chain | signal peptide:1-20 chain:21-851 |
| checksum | AEC56C4477C003B2 |
| comment | FUNCTION Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity).FUNCTION (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL.SUBUNIT Forms homodimers and homooligomers (PubMed:11323414). Interacts with DYNLT4 (PubMed:16982625). Interacts with integrin ITGA5:ITGB1; this interaction promotes the internalization and trafficking of ITGA5:ITGB1 into endocytic vesicles (PubMed:22562249). Interacts with TGFB1, BMP2, BMP5, BMP7 or GDF5 and inhibin A via the ligand binding domains (PubMed:18184661). Interacts with ALK3/BMPR1A; this interaction results in the cell surface retention of BMPR1A (PubMed:19726563). Interacts with ALK6/BMPR1B; this interaction enhances BMPR1B-mediated stimulation of the BMP signaling pathway (PubMed:19726563). Interacts with the scaffolding protein beta-arrestin2/ARRB2; this interaction mediates internalization of TGFBR3 and thus regulates migration, actin cytoskeleton and activation of CDC42 (PubMed:12958365, PubMed:18184661, PubMed:19416857, PubMed:19325136).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus trimer complex composed of gH, gL, and gO; these interactions may promote HCMV cell entry in specific cell types.INTERACTION Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.ALTERNATIVE PRODUCTS Extensively modified by glycosaminoglycan groups (GAG).PTM Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-840 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Transforming growth factor beta receptor type 3 shortName: TGF-beta receptor type 3 shortName: TGFR-3 alternativeName: Betaglycan alternativeName: Transforming growth factor beta receptor III shortName: TGF-beta receptor type III |
| geneName | TGFBR3 |
| identifier | Q03167 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond Extracellular matrix Glycoprotein Membrane Phosphoprotein Proteoglycan Proteomics identification Receptor Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TGFBR3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997477] ENSEMBL:ENSG00000069702 TGFBR3 [Homo sapiens] |
| secondaryIdentifier | TGBR3_HUMAN A0AUW8 A8K5N0 B9EG88 Q5T2T4 Q5U731 Q9UGI2 |
| sequenceLength | 851 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q03167-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q03167-2 TGFBR3 (8967226)
