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Details on Person UniProt:P13631-3 RARG
| Class:Id | ReferenceIsoform:8967149 |
|---|---|
| _chainChangeLog | chain:1-454 added on Fri February 17 2017 |
| _displayName | UniProt:P13631-3 RARG |
| _timestamp | 2024-11-03 19:48:09 |
| chain | chain:1-454 |
| checksum | 1EE27B22772D4AFD |
| comment | FUNCTION Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).SUBUNIT Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.INTERACTION Isoforms differ only in their N-terminal regions.TISSUE SPECIFICITY Expressed in aortic endothelial cells (at protein level).DOMAIN Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily.SEQUENCE CAUTION Retinoic acid receptor entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Retinoic acid receptor gamma shortName: RAR-gamma alternativeName: Nuclear receptor subfamily 1 group B member 3 |
| geneName | RARG NR1B3 |
| identifier | P13631 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm DNA-binding Isopeptide bond Metal-binding Methylation Nucleus Proteomics identification Receptor Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RARG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002008] ENSEMBL:ENSG00000172819 RARG [Homo sapiens] |
| secondaryIdentifier | RARG_HUMAN B7Z492 B7Z4F1 B7ZAE4 J3KNP6 P22932 Q15281 Q52LZ8 Q9BYX8 Q9H1I3 Q9UJ38 |
| sequenceLength | 454 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P13631-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P13631-3 RARG (8967149)
