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Details on Person UniProt:P01308-1 INS
| Class:Id | ReferenceIsoform:8967023 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 17 2017;peptide:25-54 added on Fri February 17 2017;propeptide:57-87 added on Fri February 17 2017;peptide:90-110 added on Fri February 17 2017 |
| _displayName | UniProt:P01308-1 INS |
| _timestamp | 2026-05-15 21:13:01 |
| chain | signal peptide:1-24 peptide:25-54 propeptide:57-87 peptide:90-110 |
| checksum | C2C3B23B85E520E5 |
| comment | FUNCTION Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SUBUNIT Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173).INTERACTION Expressed by pancreatic beta-cells (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.PHARMACEUTICAL Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.SIMILARITY Belongs to the insulin family.SEQUENCE CAUTION Protein of the 20th century - Issue 9 of April 2001ONLINE INFORMATION Insulin entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Insulin component recommendedName: Insulin B chain /component component recommendedName: Insulin A chain /component |
| geneName | INS |
| identifier | P01308 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Carbohydrate metabolism Cleavage on pair of basic residues Diabetes mellitus Direct protein sequencing Disease variant Disulfide bond Glucose metabolism Hormone Pharmaceutical Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | INS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8931794] ENSEMBL:ENSG00000254647 INS [Homo sapiens] |
| secondaryIdentifier | INS_HUMAN Q5EEX2 |
| sequenceLength | 110 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P01308-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P01308-1 INS (8967023)
