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Details on Person UniProt:Q9BRI3-1 SLC30A2
| Class:Id | ReferenceIsoform:8966854 |
|---|---|
| _chainChangeLog | chain:1-323 added on Fri February 17 2017;chain:1-323 for 8966854 removed on Fri February 24 2023;chain:1-372 for 8966854 added on Fri February 24 2023 |
| _displayName | UniProt:Q9BRI3-1 SLC30A2 |
| _timestamp | 2026-02-20 21:56:20 |
| chain | chain:1-372 |
| checksum | 0B004533D3B6D29C |
| comment | FUNCTION Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614).FUNCTION Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane.CATALYTIC ACTIVITY Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)SUBUNIT Homodimer (PubMed:22733820). Interacts (via lysosomal targeting motif) with AP3D1; in AP-3-mediated transport to lysosomes (PubMed:25808614). Interacts with TMEM163 (PubMed:36204728).INTERACTION Localization to lysosomes is induced by TNF.SUBCELLULAR LOCATION Phosphorylated at Ser-296. Phosphorylation at Ser-296 prevents localization to lysosomes. Dephosphorylation of Ser-296 which triggers localization to lysosomes, accumulation of zinc into lysosomes and lysosomal-mediated cell death is induced by TNF.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="18"Proton-coupled zinc antiporter SLC30A2 alternativeName: fullName evidence="19"Solute carrier family 30 member 2 alternativeName: fullName evidence="13"Zinc transporter 2 shortName evidence="13"ZnT-2 |
| geneName | SLC30A2 ZNT2 |
| identifier | Q9BRI3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Antiport Cell membrane Cytoplasmic vesicle Disease variant Endosome Ion transport Lysosome Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SLC30A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5662478] ENSEMBL:ENSG00000158014 SLC30A2 [Homo sapiens] |
| secondaryIdentifier | ZNT2_HUMAN Q71RC8 |
| sequenceLength | 372 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BRI3-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BRI3-1 SLC30A2 (8966854)
