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Details on Person UniProt:P40938-1 RFC3
| Class:Id | ReferenceIsoform:8966723 |
|---|---|
| _chainChangeLog | chain:1-356 added on Fri February 17 2017 |
| _displayName | UniProt:P40938-1 RFC3 |
| _timestamp | 2025-05-21 21:14:35 |
| chain | chain:1-356 |
| checksum | 820C11675A2C63A5 |
| comment | FUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA.SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA (PubMed:8999859, PubMed:9488738). Forms an heterotetrameric complex with RFC2, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA (PubMed:9488738). The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17 (PubMed:10884395, PubMed:11572977). Interacts with CNTD1; this interaction facilitates crossover formation (By similarity).INTERACTION Belongs to the activator 1 small subunits family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Replication factor C subunit 3 alternativeName: Activator 1 38 kDa subunit shortName: A1 38 kDa subunit alternativeName: Activator 1 subunit 3 alternativeName: Replication factor C 38 kDa subunit shortName: RF-C 38 kDa subunit shortName: RFC38 |
| geneName | RFC3 |
| identifier | P40938 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing DNA replication DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RFC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999117] ENSEMBL:ENSG00000133119 RFC3 [Homo sapiens] |
| secondaryIdentifier | RFC3_HUMAN C9JU95 O15252 Q5W0E8 |
| sequenceLength | 356 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P40938-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P40938-1 RFC3 (8966723)
