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Details on Person UniProt:O95600-1 KLF8
| Class:Id | ReferenceIsoform:8966139 |
|---|---|
| _chainChangeLog | chain:1-359 added on Fri February 17 2017 |
| _displayName | UniProt:O95600-1 KLF8 |
| _timestamp | 2024-11-03 19:56:50 |
| chain | chain:1-359 |
| checksum | F8FDCC1FD477C04F |
| comment | FUNCTION Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).SUBUNIT Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, and PIAS4; the interaction with each ligase sumoylates KLF8.SUBCELLULAR LOCATION Ubiquitous.DOMAIN The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF8, the motif is inactive.PTM Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.SIMILARITY Belongs to the Sp1 C2H2-type zinc-finger protein family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Krueppel-like factor 8 alternativeName: Basic krueppel-like factor 3 alternativeName: Zinc finger protein 741 |
| geneName | KLF8 BKLF3 ZNF741 |
| identifier | O95600 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | KLF8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994298] ENSEMBL:ENSG00000102349 KLF8 [Homo sapiens] |
| secondaryIdentifier | KLF8_HUMAN B4DJN3 E7EQQ8 L0R3U8 L0R4U2 Q2M246 Q59GV5 Q5HYQ5 Q5JXP7 Q6MZJ7 Q9UGC4 |
| sequenceLength | 359 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O95600-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O95600-1 KLF8 (8966139)
