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Details on Person UniProt:Q9UBK2-7 PPARGC1A
| Class:Id | ReferenceIsoform:8965764 |
|---|---|
| _chainChangeLog | chain:1-798 added on Fri February 17 2017 |
| _displayName | UniProt:Q9UBK2-7 PPARGC1A |
| _timestamp | 2026-02-20 22:14:40 |
| chain | chain:1-798 |
| checksum | 97DDD3643051A5F1 |
| comment | FUNCTION Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).SUBUNIT Homooligomer (PubMed:10713165). Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC (PubMed:17050673). Interacts with FOXO1 (By similarity). Interacts with NR5A2 (PubMed:28363985, PubMed:32433991).INTERACTION Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.INDUCTION Transcription is repressed by ZNF746 which binds to 'insulin response sequences' its promoter.PTM Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.PTM Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A (PubMed:16753578, PubMed:20005308, PubMed:23142079). Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation (PubMed:20005308).PTM Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative promoter usage.MISCELLANEOUS Produced by alternative promoter usage. May be involved in gluconeogenesis, liver-specific. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha shortName evidence="20"PGC-1-alpha shortName evidence="18"PPAR-gamma coactivator 1-alpha shortName evidence="18"PPARGC-1-alpha alternativeName: Ligand effect modulator 6 |
| geneName | PPARGC1A LEM6 PGC1 PGC1A PPARGC1 |
| identifier | Q9UBK2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative promoter usage Alternative splicing Biological rhythms Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PPARGC1A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998534] ENSEMBL:ENSG00000109819 PPARGC1A [Homo sapiens] |
| secondaryIdentifier | PRGC1_HUMAN B7Z406 D6RBF3 G8DM16 I3RTT5 I3RTT6 I3RTT7 I3RTT8 I3RTT9 Q3LIG1 Q4W5M7 Q9UN32 |
| sequenceLength | 798 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9UBK2-7 |
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No pathways have been reviewed or authored by UniProt:Q9UBK2-7 PPARGC1A (8965764)
