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Details on Person UniProt:P27448-8 MARK3
| Class:Id | ReferenceIsoform:8965686 |
|---|---|
| _chainChangeLog | chain:1-753 added on Fri February 17 2017 |
| _displayName | UniProt:P27448-8 MARK3 |
| _timestamp | 2025-02-21 20:00:57 |
| chain | chain:1-753 |
| checksum | B50B3C145E896B0B |
| comment | FUNCTION Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by phosphorylation on Thr-211. Inhibited by phosphorylation on Thr-564.SUBUNIT Interacts with MAPT/TAU (PubMed:23666762). Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5 (PubMed:28087714). Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ (PubMed:16959763). Interacts with PKP2 (via N-terminus) (PubMed:12941695). Interacts with CDC25C (PubMed:12941695). Interacts with KSR1 (PubMed:12941695).INTERACTION Ubiquitous.PTM Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity (PubMed:15084291).DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: MAP/microtubule affinity-regulating kinase 3 ecNumber evidence="7 10 12"2.7.11.1 alternativeName: C-TAK1 shortName: cTAK1 alternativeName: Cdc25C-associated protein kinase 1 alternativeName: ELKL motif kinase 2 shortName: EMK-2 alternativeName: Protein kinase STK10 alternativeName: Ser/Thr protein kinase PAR-1 shortName: Par-1a alternativeName: Serine/threonine-protein kinase p78 |
| geneName | MARK3 CTAK1 EMK2 |
| identifier | P27448 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cell membrane Cell projection Cytoplasm Disease variant Kinase Membrane Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MARK3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962236] ENSEMBL:ENSG00000075413 MARK3 [Homo sapiens] |
| secondaryIdentifier | MARK3_HUMAN A0A0A0MQR8 A0A0A0MST9 A0A0A0MT23 O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34 |
| sequenceLength | 753 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P27448-8 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P27448-8 MARK3 (8965686)
