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Details on Person UniProt:Q9Y5R6-1 DMRT1
| Class:Id | ReferenceIsoform:8965564 |
|---|---|
| _chainChangeLog | chain:1-373 added on Fri February 17 2017 |
| _displayName | UniProt:Q9Y5R6-1 DMRT1 |
| _timestamp | 2026-02-20 21:29:11 |
| chain | chain:1-373 |
| checksum | 23348B2C4A4733A1 |
| comment | FUNCTION Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).SUBCELLULAR LOCATION Testis-specific. Expressed in prostate cancer (at protein level).DEVELOPMENTAL STAGE Expressed in the genital ridges of six-week-old male embryos. Becomes confined to the forming seminiferous tubules (probably Sertoli cells) at seven weeks. Not detected in female embryos.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the DMRT family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Doublesex- and mab-3-related transcription factor 1 alternativeName: DM domain expressed in testis protein 1 |
| geneName | DMRT1 DMT1 |
| identifier | Q9Y5R6 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Developmental protein Differentiation DNA-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Sexual differentiation Transcription Transcription regulation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | DMRT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994774] ENSEMBL:ENSG00000137090 DMRT1 [Homo sapiens] |
| secondaryIdentifier | DMRT1_HUMAN B2R913 Q6T1H8 Q6T1H9 Q8IW77 |
| sequenceLength | 373 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y5R6-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y5R6-1 DMRT1 (8965564)
