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Details on Person UniProt:P54687-4 BCAT1
| Class:Id | ReferenceIsoform:8965487 |
|---|---|
| _chainChangeLog | chain:1-386 added on Fri February 17 2017 |
| _displayName | UniProt:P54687-4 BCAT1 |
| _timestamp | 2025-02-21 19:04:43 |
| chain | chain:1-386 |
| checksum | A43535303A702512 |
| comment | FUNCTION Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.CATALYTIC ACTIVITY L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamateCATALYTIC ACTIVITY L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamateCATALYTIC ACTIVITY L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamateCOFACTOR The branched-chain-amino-acid aminotransferase, activity is inhibited by anticonvulsant drug gabapentin.SUBUNIT Homodimer.INTERACTION During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.SIMILARITY Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Branched-chain-amino-acid aminotransferase, cytosolic shortName: BCAT(c) ecNumber evidence="1"2.6.1.42 |
| geneName | BCAT1 BCT1 ECA39 |
| identifier | P54687 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Amino-acid biosynthesis Aminotransferase Branched-chain amino acid biosynthesis Cytoplasm Lipid metabolism Proteomics identification Pyridoxal phosphate Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | BCAT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957629] ENSEMBL:ENSG00000060982 BCAT1 [Homo sapiens] |
| secondaryIdentifier | BCAT1_HUMAN B3KY27 B7Z2M5 B7Z5L0 F5H5E4 Q68DQ7 Q96MY9 |
| sequenceLength | 386 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P54687-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P54687-4 BCAT1 (8965487)
