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Details on Person UniProt:O75154-3 RAB11FIP3
| Class:Id | ReferenceIsoform:8965324 |
|---|---|
| _chainChangeLog | chain:1-756 added on Fri February 17 2017 |
| _displayName | UniProt:O75154-3 RAB11FIP3 |
| _timestamp | 2024-11-03 20:21:05 |
| chain | chain:1-756 |
| checksum | 264CEC399F28AFB9 |
| comment | FUNCTION Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery (PubMed:15601896, PubMed:16148947, PubMed:17394487, PubMed:17628206, PubMed:18511905, PubMed:19327867, PubMed:20026645, PubMed:25673879, PubMed:26258637, PubMed:31204173). Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex (PubMed:20026645). The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle (PubMed:17394487, PubMed:20026645). Facilitates the interaction between dynein and dynactin and activates dynein processivity (PubMed:25035494). Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes (By similarity). The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission (PubMed:15601896, PubMed:16148947). The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes (PubMed:17628206, PubMed:18511905). Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:26258637, PubMed:31204173). Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin (PubMed:25673879). Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway (PubMed:31204173). May play a role in breast cancer cell motility by regulating actin cytoskeleton (PubMed:19327867).SUBUNIT Homodimer (PubMed:17007872, PubMed:17030804). Interacts with RAB11A; the interaction is direct and is required for the recruitment to endosomes (PubMed:11495908, PubMed:15601896, PubMed:17030804, PubMed:17229837, PubMed:31204173). Interacts with RAB11B (PubMed:11495908). Forms a ternary complex with RAB11A and dynein intermediate chain DYNC1LI1; RAB11FIP3 links RAB11A to dynein and the interaction regulates endocytic trafficking (PubMed:20026645). Interacts with dynein intermediate chain and dynactin (DCTN1); the interaction activates dynein processivity (PubMed:25035494). Interacts with ARF6 and EXOC7; the interaction serves for recruitment and tethering of recycling endosomes-derived vesicles to the cleavage furrow/midbody (PubMed:16148947, PubMed:17030804, PubMed:17628206). Interacts with RACGAP1/MgcRacGAP; the interaction occurs at late telophase and is required for recruitment and tethering of recycling endosomes-derived vesicles to the cleavage furrow/midbody (PubMed:18511905). Forms a complex with RAB11A and Rabin8/RAB3IP, probably a heterohexamer with two of each protein subunit, where RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking (PubMed:26258637, PubMed:31204173). Forms a complex containing RAB11A, ASAP1, RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport (PubMed:25673879, PubMed:26258637). Interacts with RAB11FIP4 (PubMed:12470645). Interacts with RAB25 (PubMed:11495908).INTERACTION During interphase, localized in vesicles continuously moving from peripheral sorting endosomes in the cell towards the pericentrosomal endosomal recycling compartment (ERC) (PubMed:17394487, PubMed:20026645). In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates localization to the midbody (PubMed:16148947). Localized to the Golgi and TGN when interacting with RHO in photoreceptors (PubMed:25673879). Localized to rhodopsin transport carriers when interacting with RAB11A and ASAP1 in photoreceptors (PubMed:25673879).ALTERNATIVE PRODUCTS The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).PTM Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.CAUTION Was initially shown not to interact with ARF5 (PubMed:16148947). Another study later demonstrated the interaction (PubMed:17030804). |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="25"Rab11 family-interacting protein 3 shortName evidence="29"FIP3 shortName evidence="27"FIP3-Rab11 shortName evidence="25"Rab11-FIP3 alternativeName: fullName evidence="28"Arfophilin-1 alternativeName: fullName evidence="24"EF hands-containing Rab-interacting protein shortName evidence="24"Eferin alternativeName: MU-MB-17.148 |
| geneName | RAB11FIP3 ARFO1 KIAA0665 |
| identifier | O75154 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Endosome Golgi apparatus Membrane Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RAB11FIP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002014] ENSEMBL:ENSG00000090565 RAB11FIP3 [Homo sapiens] |
| secondaryIdentifier | RFIP3_HUMAN B0QYI8 B0QYT8 B1AHQ0 B4DEI7 B4DZR6 Q4VXV7 Q7Z5E9 Q9H155 Q9H1G0 Q9NUI0 |
| sequenceLength | 756 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75154-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75154-3 RAB11FIP3 (8965324)
