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Details on Person UniProt:P51572-2 BCAP31
| Class:Id | ReferenceIsoform:8965079 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-246 added on Fri February 17 2017;initiator methionine:1 for 8965079 removed on Fri Nov 03 2023;initiator methionine: for 8965079 added on Fri Nov 03 2023;initiator methionine: for 8965079 removed on Fri Aug 15 2025;initiator methionine:1 for 8965079 added on Fri Aug 15 2025 |
| _displayName | UniProt:P51572-2 BCAP31 |
| _timestamp | 2025-08-15 21:51:20 |
| chain | initiator methionine:1 chain:2-246 |
| checksum | D34367F870D6EB00 |
| comment | FUNCTION Functions as a chaperone protein (PubMed:18287538, PubMed:9396746). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:18287538, PubMed:9396746). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:18287538, PubMed:9396746). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671).SUBUNIT Homodimer and heterodimer with BCAP29 (PubMed:23967155, PubMed:9334338). Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1 (PubMed:11917123, PubMed:31206022, PubMed:9334338). Forms a complex (via C-terminus) with TOMM40 which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria; within the complex BCAP31 interacts directly with unprocessed and processed NDUFS4 and NDUFB11 (PubMed:31206022). Interacts with VDAC1 (PubMed:31206022). Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins (By similarity). Interacts with HACD2 (PubMed:15024066). Interacts with DNM1L; may form part of a larger protein complex at the endoplasmic reticulum-mitochondrial interface during mitochondrial fission (PubMed:24196833).SUBUNIT (Microbial infection) Interacts (via C-terminus) with HRSV membrane protein SH; this interaction is direct.INTERACTION May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746). Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022).SUBCELLULAR LOCATION (Microbial infection) Upon SV40 infection, colocalizes with DNAJC18, DNAJB12 and DNAJB14 in punctate structures within the endoplasmic reticulum membrane.ALTERNATIVE PRODUCTS Ubiquitous. Highly expressed in neurons and discrete endocrine cells.PTM Cleaved by CASP8 and other caspases.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE BCAP31 is deleted in the chromosome Xq28 deletion syndrome which involves BCAP31 and the and the promoter region of ABCD1.SIMILARITY Belongs to the BCAP29/BCAP31 family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: B-cell receptor-associated protein 31 shortName: BCR-associated protein 31 shortName: Bap31 alternativeName: 6C6-AG tumor-associated antigen alternativeName: Protein CDM alternativeName: p28 |
| geneName | BCAP31 BAP31 DXS1357E |
| identifier | P51572 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Coiled coil Deafness Direct protein sequencing Dystonia Endoplasmic reticulum ER-Golgi transport Host-virus interaction Intellectual disability Membrane Protein transport Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | BCAP31 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991732] ENSEMBL:ENSG00000185825 BCAP31 [Homo sapiens] |
| secondaryIdentifier | BAP31_HUMAN B3KQ79 D3DWV5 Q13836 Q96CF0 |
| sequenceLength | 246 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P51572-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P51572-2 BCAP31 (8965079)
