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Details on Person UniProt:P31431-2 SDC4
| Class:Id | ReferenceIsoform:8964965 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 17 2017;chain:19-198 added on Fri February 17 2017 |
| _displayName | UniProt:P31431-2 SDC4 |
| _timestamp | 2024-11-03 20:07:39 |
| chain | signal peptide:1-18 chain:19-198 |
| checksum | 8229AA2733F77A10 |
| comment | FUNCTION Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).SUBUNIT Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP (PubMed:12842047, PubMed:16007225, PubMed:16533050). Interacts with DNM2; this interaction is markedly enhanced at focal ahesion site upon induction of focal adhesions and stress-fiber formation (By similarity).INTERACTION Shedding of the ectodomain produces a soluble form.SUBCELLULAR LOCATION Detected in fibroblasts (at protein level) (PubMed:1500433, PubMed:36213313). Also expressed in epithelial cells (PubMed:1500433).PTM Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.PTM O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.MISCELLANEOUS Soluble form, lacks the transmembrane domain.SIMILARITY Belongs to the syndecan proteoglycan family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="15"Syndecan-4 shortName: SYND4 alternativeName: Amphiglycan alternativeName: Ryudocan core protein |
| geneName | SDC4 |
| identifier | P31431 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Glycoprotein Heparan sulfate Membrane Proteoglycan Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SDC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991548] ENSEMBL:ENSG00000124145 SDC4 [Homo sapiens] |
| secondaryIdentifier | SDC4_HUMAN O00773 Q16833 Q53FN9 Q6FGN3 |
| sequenceLength | 198 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P31431-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P31431-2 SDC4 (8964965)
