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Details on Person UniProt:O09114-1 Ptgds
| Class:Id | ReferenceIsoform:8964934 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 17 2017;chain:25-189 added on Fri February 17 2017 |
| _displayName | UniProt:O09114-1 Ptgds |
| _timestamp | 2023-11-03 15:39:24 |
| chain | signal peptide:1-24 chain:25-189 |
| checksum | C2C0B3E3B5928643 |
| comment | FUNCTION Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10781097, PubMed:11751991, PubMed:12077186, PubMed:17715133, PubMed:19546224, PubMed:19833210, PubMed:8922532, PubMed:9892701). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557).CATALYTIC ACTIVITY prostaglandin H2 = prostaglandin D2BIOPHYSICOCHEMICAL PROPERTIES Monomer.SUBCELLULAR LOCATION Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.ALTERNATIVE PRODUCTS Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. In the male reproductive system, it is expressed in the testis, efferent ducts and epididymis, and is secreted into the seminal fluid. In the eye, it is expressed in the pigmented epithelium of the retina and the nonpigmented epithelium of the ciliary body, and secreted into the aqueous humor. Low levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including the ear, heart and lung.DEVELOPMENTAL STAGE Initially detected at 14.5 dpc in the mesenchymal cells of the brain. Later in development, observed in the choroid plexus and within single cells in the brain.INDUCTION By IL-1 beta and thyroid hormone. Probably induced by dexamethasone, dihydrotestosterone, progesterone, retinoic acid and retinal. Repressed by the Notch-Hes signaling pathway.DOMAIN Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.DISRUPTION PHENOTYPE Mutant mice show decreased susceptibility to passive cutaneous anaphylaxis associated with decreased mast cell degranulation.SIMILARITY Belongs to the calycin superfamily. Lipocalin family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Prostaglandin-H2 D-isomerase ecNumber evidence="9 10"5.3.99.2 alternativeName: Glutathione-independent PGD synthase alternativeName: Lipocalin-type prostaglandin-D synthase alternativeName: Prostaglandin-D2 synthase shortName: L-PGDS shortName: PGD2 synthase shortName: PGDS2 |
| geneName | Ptgds |
| identifier | O09114 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Disulfide bond Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Glycoprotein Golgi apparatus Isomerase Lipid biosynthesis Lipid metabolism Mast cell degranulation Membrane Nucleus Prostaglandin biosynthesis Prostaglandin metabolism Pyrrolidone carboxylic acid Reference proteome Secreted Signal Transport |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Ptgds |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PTGDS_MOUSE O09157 O35091 Q3V2G5 Q62169 |
| sequenceLength | 189 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | O09114-1 |
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No pathways have been reviewed or authored by UniProt:O09114-1 Ptgds (8964934)
