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Details on Person CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex

Class:Id	Reaction:8964634
_displayName	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
_doRelease	TRUE
_timestamp	2018-08-29 10:55:58
authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8964631] Varusai, Thawfeek, 2017-02-17
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
input	[EntityWithAccessionedSequence:449545] CDC42 [plasma membrane] [Homo sapiens] [Complex:8964608] G-protein beta-gamma complex:PAK1:ARHGEF6 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8964617] Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42
modified	[InstanceEdit:8964656] Varusai, Thawfeek, 2017-02-17 [InstanceEdit:8979199] Varusai, Thawfeek, 2017-02-22 [InstanceEdit:9014394] Varusai, Thawfeek, 2017-07-28 [InstanceEdit:9016699] Varusai, Thawfeek, 2017-08-15 [InstanceEdit:9617617] Varusai, Thawfeek, 2018-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
output	[Complex:8964627] G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8964619] PAK1 binds ARHGEF6 [Homo sapiens] [Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Homo sapiens] [Reaction:418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Homo sapiens] [Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens] [Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens] [Reaction:392874] Dissociation of the Prostacyclin receptor:Gs complex [Homo sapiens] [Reaction:392021] Dissociation of the alpha-2 adrenergic receptor:Gz complex [Homo sapiens] [Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens] [Reaction:749452] The Ligand:GPCR:Gq complex dissociates [Homo sapiens] [Reaction:749454] The Ligand:GPCR:Gi complex dissociates [Homo sapiens] [Reaction:751024] The Ligand:GPCR:Gz complex dissociates [Homo sapiens] [Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens] [Reaction:3965447] G-protein subunits dissociate from WNT:FZD complex [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9617615] Goedhart, Joachim, 2018-08-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8964648] R-HSA-8964634.2
summation	[Summation:8964597] G-Protein Coupled Receptors (GPCR) sense extracellular signa...
(hasEvent)	[Pathway:8964616] G beta:gamma signalling through CDC42 [Homo sapiens]
(precedingEvent)	[Reaction:8964604] CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated [Homo sapiens]
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No pathways have been reviewed or authored by CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (8964634)