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Details on Person TOP2A gene gene expression is repressed by the DREAM complex

Class:Id	BlackBoxEvent:8964531
_displayName	TOP2A gene gene expression is repressed by the DREAM complex
_doRelease	TRUE
_timestamp	2017-02-28 16:48:32
authored	[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8964529] Orlic-Milacic, Marija, 2017-02-17
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:8962659] TOP2A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TOP2A gene gene expression is repressed by the DREAM complex
output	[EntityWithAccessionedSequence:1362276] TOP2A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8964475] DREAM complex binds the TOP2A gene promoter [Homo sapiens] [Reaction:1362261] p130 (RBL2) associates with MuvB to form DREAM complex [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:8964532] Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]'
regulationReference	[RegulationReference:9642902] Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2011-09-20
reviewed	[InstanceEdit:1538129] MacPherson, D, 2011-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8964533] R-HSA-8964531.4
summation	[Summation:8964530] The DREAM complex directly represses the TOP2A gene transcri...
(hasEvent)	[Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex [Homo sapiens]
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No pathways have been reviewed or authored by TOP2A gene gene expression is repressed by the DREAM complex (8964531)