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Details on Person Gq-BTK complex dissociates to Active BTK and Gq

Class:Id	Reaction:8964340
_displayName	Gq-BTK complex dissociates to Active BTK and Gq
_doRelease	TRUE
_timestamp	2018-09-13 09:09:55
authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
input	[Complex:8964303] Active Gq:Active BTK [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8964321] Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit [LiteratureReference:8964338] Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase [LiteratureReference:9006764] Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization
modified	[InstanceEdit:8964426] Varusai, Thawfeek, 2017-02-16 [InstanceEdit:8979199] Varusai, Thawfeek, 2017-02-22 [InstanceEdit:9006763] Varusai, Thawfeek, 2017-05-18 [InstanceEdit:9014394] Varusai, Thawfeek, 2017-07-28 [InstanceEdit:9016697] Varusai, Thawfeek, 2017-08-15 [InstanceEdit:9618883] Varusai, Thawfeek, 2018-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Gq-BTK complex dissociates to Active BTK and Gq
output	[EntityWithAccessionedSequence:8964323] Active BTK [cytosol] [Homo sapiens] [Complex:114534] G-protein alpha (q/11): GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8964284] BTK in active Gq-BTK complex is activated [Homo sapiens] [Reaction:8964280] Active Gq binds BTK [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9618881] Huang, Xin-Yun, 2018-09-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8964401] R-HSA-8964340.2
summation	[Summation:8964305] G-Protein Coupled Receptors (GPCR) sense extracellular signa...
(hasEvent)	[Pathway:416476] G alpha (q) signalling events [Homo sapiens]
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No pathways have been reviewed or authored by Gq-BTK complex dissociates to Active BTK and Gq (8964340)