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Details on Person PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex

Class:Id	Reaction:8964317
_displayName	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
_doRelease	TRUE
_timestamp	2018-09-13 09:10:01
authored	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16
edited	[InstanceEdit:9014287] Varusai, Thawfeek, 2017-07-27
input	[Complex:8964267] PIP3:Active BTK:G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8964285] Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits [LiteratureReference:8964339] G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase
modified	[InstanceEdit:8964426] Varusai, Thawfeek, 2017-02-16 [InstanceEdit:9014394] Varusai, Thawfeek, 2017-07-28 [InstanceEdit:9016699] Varusai, Thawfeek, 2017-08-15 [InstanceEdit:9618883] Varusai, Thawfeek, 2018-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:8964323] Active BTK [cytosol] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8964271] BTK in PIP3:BTK:G beta-gamma complex is activated [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9618881] Huang, Xin-Yun, 2018-09-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8964403] R-HSA-8964317.2
summation	[Summation:8964265] G-Protein Coupled Receptors (GPCR) sense extracellular signa...
(hasEvent)	[Pathway:8964315] G beta:gamma signalling through BTK [Homo sapiens]
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No pathways have been reviewed or authored by PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (8964317)