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Details on Person Diagram of Plasma lipoprotein assembly, remodeling, and clearance and Defective ABCA1 causes TGD

Class:IdPathwayDiagram:8964196
_displayNameDiagram of Plasma lipoprotein assembly, remodeling, and clearance and Defective ABCA1 causes TGD
_timestamp2022-02-15 19:59:22
created[InstanceEdit:8964197] D'Eustachio, Peter, 2017-02-15
height1626
modified[InstanceEdit:8964415] D'Eustachio, Peter, 2017-02-16
[InstanceEdit:8964440] D'Eustachio, Peter, 2017-02-16
[InstanceEdit:8964536] D'Eustachio, Peter, 2017-02-17
[InstanceEdit:8978867] D'Eustachio, Peter, 2017-02-20
[InstanceEdit:8979295] D'Eustachio, Peter, 2017-02-23
[InstanceEdit:8979296] D'Eustachio, Peter, 2017-02-23
[InstanceEdit:8979297] D'Eustachio, Peter, 2017-02-23
[InstanceEdit:8979318] D'Eustachio, Peter, 2017-02-24
[InstanceEdit:8979319] D'Eustachio, Peter, 2017-02-24
[InstanceEdit:8980227] D'Eustachio, Peter, 2017-02-27
[InstanceEdit:9644175] D'Eustachio, Peter, 2019-04-09
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9694015] Jassal, Bijay, 2020-07-08
[InstanceEdit:9733402] Jassal, Bijay, 2021-06-04
[InstanceEdit:9734446] Jassal, Bijay, 2021-06-17
[InstanceEdit:9735900] Jassal, Bijay, 2021-07-05
[InstanceEdit:9737613] Jassal, Bijay, 2021-07-21
[InstanceEdit:9737731] Jassal, Bijay, 2021-07-21
[InstanceEdit:9737790] Jassal, Bijay, 2021-07-22
[InstanceEdit:9737800] Jassal, Bijay, 2021-07-22
[InstanceEdit:9737803] Jassal, Bijay, 2021-07-22
[InstanceEdit:9737804] Jassal, Bijay, 2021-07-22
[InstanceEdit:9748639] Jassal, Bijay, 2021-07-23
[InstanceEdit:9751092] Jassal, Bijay, 2021-08-18
[InstanceEdit:9751102] Jassal, Bijay, 2021-08-18
[InstanceEdit:9765103] May, Bruce, 2022-02-14
[InstanceEdit:9765529] D'Eustachio, Peter, 2022-02-15
[InstanceEdit:9765533] D'Eustachio, Peter, 2022-02-15
representedPathway[Pathway:174824] Plasma lipoprotein assembly, remodeling, and clearance [Homo sapiens]
[Pathway:5682113] Defective ABCA1 causes TGD [Homo sapiens]
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<Properties> <displayName>APOA4,APOA5,APOC2,CIDEC,FGF21 genes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="188" reactomeId="6784718" position="155 321" bounds="91 303 129 37" textPosition="91 303"> <Properties> <displayName>APOA4,APOA5,APOC2,CIDEC,FGF21</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="191" reactomeId="6785148" position="606 275" bounds="581 264 51 23" textPosition="581 264"> <Properties> <displayName>LMF1,2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="192" reactomeId="6785190" position="533 292" bounds="498 281 71 23" textPosition="498 282" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIPC dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="193" reactomeId="6785173" position="585 389" bounds="527 378 117 23" textPosition="527 379" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIPC dimer:LMF1,2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="196" reactomeId="6785179" position="773 499" bounds="738 488 71 23" textPosition="738 489" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="199" reactomeId="1604784" position="835 533" bounds="801 518 69 31" textPosition="805 522"> <Properties> <displayName>Heparins</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="200" reactomeId="6785208" position="773 639" bounds="714 628 119 23" textPosition="714 629" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIPC dimer:heparin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="202" reactomeId="171126" position="664 698" bounds="640 683 48 31" textPosition="644 687" /> <org.gk.render.RenderableChemical id="203" reactomeId="109276" position="708 735" bounds="687 720 43 31" textPosition="691 724" /> <org.gk.render.RenderableChemical id="204" reactomeId="422024" position="846 735" bounds="828 720 37 31" textPosition="832 724"> <Properties> <displayName>FAs</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="205" reactomeId="174675" position="886 698" bounds="862 683 49 31" textPosition="866 687" /> <org.gk.render.RenderableChemical id="208" reactomeId="174602" position="1201 705" bounds="1176 690 51 31" textPosition="1180 694"> <Properties> <displayName>LCFAs</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="209" reactomeId="174798" position="1297 639" bounds="1254 621 86 37" textPosition="1253 622" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TG-depleted chylomicron</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="210" reactomeId="174608" position="1177 523" bounds="1153 512 49 23" textPosition="1153 512"> <Properties> <displayName>APOA5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="211" reactomeId="174699" position="1237 523" bounds="1213 512 49 23" textPosition="1213 512" /> <org.gk.render.RenderableProtein id="212" reactomeId="174725" position="1156 606" bounds="1132 595 49 23" textPosition="1132 595" /> <org.gk.render.RenderableChemical id="214" reactomeId="174675" position="1135 664" bounds="1111 649 49 31" textPosition="1115 653"> <Properties> <displayName>DAGs</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="217" reactomeId="174807" position="1495 683" bounds="1431 672 129 23" textPosition="1431 673" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>chylomicron remnant</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="218" reactomeId="174769" position="1570 610" bounds="1507 585 127 51" textPosition="1517 572" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="220" reactomeId="174646" position="1566 736" bounds="1546 725 40 23" textPosition="1546 725"> <Properties> <displayName>APOE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="221" reactomeId="174792" position="1721 682" bounds="1674 657 94 51" textPosition="1674 658" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="228" reactomeId="171131" position="2786 621" bounds="2771 610 30 23" textPosition="2771 611" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="229" reactomeId="266340" position="2911 679" bounds="2857 661 109 37" textPosition="2857 662" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CETP:cholesterol ester</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="230" reactomeId="266351" position="3089 655" bounds="3029 644 121 23" textPosition="3029 645" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CETP:triacylglycerol</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="231" reactomeId="266339" position="3087 579" bounds="3023 568 129 23" textPosition="3023 569" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LDL:cholesterol ester</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="232" reactomeId="5216090" position="2957 560" bounds="2938 549 39 23" textPosition="2938 549"> <Properties> <displayName>APOF</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="235" reactomeId="176877" position="2686 573" bounds="2671 562 30 23" textPosition="2671 562"> <Properties> <displayName>LPA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="236" reactomeId="176866" position="2687 681" bounds="2668 670 38 23" textPosition="2668 671" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Lp(a)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="239" reactomeId="70101" position="3373 615" bounds="3220 534 306 162" textPosition="3245 649" bgColor="250 240 240" lineColor="255 153 102" insets="3229 544 284 143"> <Components> <Component id="240" /> <Component id="245" /> <Component id="243" /> <Component id="247" /> <Component id="244" /> <Component id="251" /> <Component id="253" /> <Component id="246" /> <Component id="276" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="240" reactomeId="13946" position="3295 603" bounds="3245 558 100 91" textPosition="3248 585" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="249" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="244" reactomeId="113592" position="3354 665" bounds="3334 650 40 31" textPosition="3338 654" /> <org.gk.render.RenderableChemical id="245" reactomeId="29356" position="3389 574" bounds="3368 559 43 31" textPosition="3372 563" /> <org.gk.render.RenderableChemical id="246" reactomeId="29370" position="3474 590" bounds="3454 575 41 31" textPosition="3458 579"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="247" reactomeId="194222" position="3413 698" bounds="3370 687 87 23" textPosition="3370 688" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCG1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="249" reactomeId="216762" position="3335 585" bounds="3311 570 49 31" textPosition="3315 574" /> <org.gk.render.RenderableChemical id="251" reactomeId="29372" position="3439 564" bounds="3426 549 27 31" textPosition="3430 553"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="253" reactomeId="171095" position="3514 627" bounds="3490 612 49 31" textPosition="3494 616" /> <org.gk.render.RenderableComplex id="256" reactomeId="266083" position="3638 735" bounds="3592 717 92 37" textPosition="3592 718" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>discoidal HDL:cholesterol</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="259" reactomeId="194239" position="3806 613" bounds="3787 602 39 23" textPosition="3787 602" /> <org.gk.render.RenderableComplex id="260" reactomeId="264684" position="3762 740" bounds="3699 722 126 37" textPosition="3699 723" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LCAT:discoidal HDL complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="265" reactomeId="265523" position="3475 752" bounds="3431 741 89 23" textPosition="3431 742" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="266" reactomeId="174725" position="3385 784" bounds="3361 773 49 23" textPosition="3361 773"> <Properties> <displayName>APOC3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="267" reactomeId="174699" position="3381 842" bounds="3357 831 49 23" textPosition="3357 831"> <Properties> <displayName>APOC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="269" reactomeId="174646" position="3343 813" bounds="3323 802 40 23" textPosition="3323 802" /> <org.gk.render.RenderableComplex id="271" reactomeId="174643" position="3430 929" bounds="3367 911 127 37" textPosition="3378 898" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="273" reactomeId="8855688" position="3640 879" bounds="3580 861 120 37" textPosition="3580 862" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>enlarged spherical HDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="274" reactomeId="194227" position="3660 786" bounds="3642 775 37 23" textPosition="3642 775"> <Properties> <displayName>PLTP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="276" reactomeId="171142" position="3503 690" bounds="3488 675 30 31" textPosition="3492 679" /> <org.gk.render.RenderableChemical id="278" reactomeId="171149" position="3840 538" bounds="3816 523 49 31" textPosition="3820 527" /> <org.gk.render.RenderableChemical id="280" reactomeId="194236" position="3943 671" bounds="3905 656 76 31" textPosition="3908 660"> <Properties> <displayName>1-acyl LPC</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="281" reactomeId="171076" position="3879 715" bounds="3852 700 55 31" textPosition="3856 704"> <Properties> <displayName>CHEST</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="284" reactomeId="174720" position="3959 615" bounds="3906 603 107 24" textPosition="3908 604" /> <org.gk.render.RenderableProtein id="287" reactomeId="194115" position="3996 730" bounds="3981 719 30 23" textPosition="3981 719"> <Properties> <displayName>ALB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="288" reactomeId="264677" position="3944 842" bounds="3879 817 131 51" textPosition="3879 818" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>albumin:2-lysophosphatidylcholine complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="290" reactomeId="266308" position="3570 970" bounds="3507 952 127 37" textPosition="3507 953" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LCAT:spherical HDL complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="291" reactomeId="194239" position="3490 839" bounds="3471 828 39 23" textPosition="3471 828"> <Properties> <displayName>LCAT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="295" reactomeId="266348" position="2916 777" bounds="2870 752 93 51" textPosition="2870 753" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>spherical HDL:triacylglycerol complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="302" reactomeId="70101" position="1412 1032" bounds="1221 774 383 517" textPosition="1235 1240" bgColor="250 240 240" lineColor="255 153 102" insets="1232 781 361 500"> <Components> <Component id="303" /> <Component id="304" /> <Component id="306" /> <Component id="307" /> <Component id="311" /> <Component id="309" /> <Component id="312" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="303" reactomeId="171907" position="1445 1162" bounds="1342 1061 207 202" textPosition="1356 1218" bgColor="250 240 240" lineColor="255 153 102" insets="1353 1071 186 183"> <Components> <Component id="313" /> <Component id="317" /> <Component id="316" /> <Component id="315" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="304" reactomeId="24339" position="1380 938" bounds="1240 880 281 116" textPosition="1243 886" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="310" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="306" reactomeId="171053" position="1595 804" bounds="1576 793 38 23" textPosition="1576 793"> <Properties> <displayName>LDLR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="307" reactomeId="174749" position="1598 882" bounds="1535 857 127 51" textPosition="1535 858" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>chylomicron remnant:apoE:LDLR complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="308" reactomeId="174603" position="1714 893" bounds="1698 882 33 23" textPosition="1698 882"> <Properties> <displayName>LIPC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="310" reactomeId="174816" position="1479 956" bounds="1416 931 127 51" textPosition="1416 932" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="311" reactomeId="171143" position="1599 1004" bounds="1569 993 61 23" textPosition="1569 993" /> <org.gk.render.RenderableComplex id="313" reactomeId="174658" position="1479 1064" bounds="1416 1039 127 51" textPosition="1416 1040" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="316" reactomeId="171127" position="1551 1156" bounds="1532 1145 38 23" textPosition="1532 1145" /> <org.gk.render.RenderableComplex id="317" reactomeId="174594" position="1479 1194" bounds="1432 1169 94 51" textPosition="1432 1170" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>chylomicron remnant:apoE complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="318" reactomeId="70101" position="2219 584" bounds="1838 532 763 105" textPosition="2367 591" bgColor="250 240 240" lineColor="255 153 102" insets="1847 541 745 86"> <Components> <Component id="320" /> <Component id="321" /> <Component id="319" /> <Component id="322" /> <Component id="323" /> <Component id="324" /> <Component id="327" /> <Component id="326" /> <Component id="328" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="320" reactomeId="5216079" position="1864 533" bounds="1841 522 46 23" textPosition="1841 522" /> <org.gk.render.RenderableComplex id="321" reactomeId="8854464" position="2020 537" bounds="1981 526 79 23" textPosition="1981 527" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VLDL:VLDLR</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="323" reactomeId="8854406" position="2121 537" bounds="2078 526 86 23" textPosition="2078 527" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APOBR dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="324" reactomeId="8856140" position="2286 538" bounds="2240 522 93 33" textPosition="2242 519" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APOBR dimer:VLDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="327" reactomeId="8933252" position="2386 536" bounds="2352 525 68 23" textPosition="2352 526" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LSR trimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="328" reactomeId="8933291" position="2549 537" bounds="2499 526 101 23" textPosition="2499 527" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LSR trimer:VLDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="330" reactomeId="70101" position="2230 1100" bounds="1798 789 865 622" textPosition="1823 1355" bgColor="250 240 240" lineColor="255 153 102" insets="1808 801 842 598"> <Components> <Component id="331" /> <Component id="332" /> <Component id="333" /> <Component id="336" /> <Component id="335" /> <Component id="338" /> <Component id="340" /> <Component id="334" /> <Component id="346" /> <Component id="349" /> <Component id="350" /> <Component id="358" /> <Component id="376" /> <Component id="388" /> <Component id="390" /> <Component id="392" /> <Component id="395" /> <Component id="398" /> <Component id="397" /> <Component id="396" /> <Component id="402" /> <Component id="404" /> <Component id="409" /> <Component id="410" /> <Component id="412" /> <Component id="415" /> <Component id="417" /> <Component id="418" /> <Component id="423" /> <Component id="416" /> <Component id="377" /> <Component id="384" /> <Component id="383" /> <Component id="668" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="331" reactomeId="24339" position="2546 877" bounds="2486 831 121 92" textPosition="2484 834" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>clathrin-coated endocytic vesicle membrane</displayName> </Properties> <Components> <Component id="347" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="332" reactomeId="171907" position="2533 1074" bounds="2467 989 133 171" textPosition="2469 1114" bgColor="250 240 240" lineColor="255 153 102" insets="2477 998 114 152"> <Properties> <displayName>endosome lumen</displayName> </Properties> <Components> <Component id="351" /> <Component id="355" /> <Component id="354" /> <Component id="357" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="333" reactomeId="161320" position="2307 1046" bounds="2166 840 283 412" textPosition="2179 1205" bgColor="250 240 240" lineColor="255 153 102" insets="2176 854 260 387"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="363" /> <Component id="364" /> <Component id="365" /> <Component id="366" /> <Component id="361" /> <Component id="371" /> <Component id="369" /> <Component id="370" /> <Component id="374" /> <Component id="372" /> <Component id="373" /> <Component id="359" /> <Component id="362" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="335" reactomeId="8933254" position="2416 794" bounds="2370 783 93 23" textPosition="2370 784" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LSR trimer:LDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="336" reactomeId="8933252" position="2569 794" bounds="2535 783 68 23" textPosition="2535 784" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="338" reactomeId="171100" position="2658 822" bounds="2600 811 116 23" textPosition="2600 812" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="340" reactomeId="171053" position="2657 1009" bounds="2638 998 38 23" textPosition="2638 998" /> <org.gk.render.RenderableComplex id="347" reactomeId="171108" position="2588 903" bounds="2530 892 116 23" textPosition="2530 893" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LDL:LDLR complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="349" reactomeId="171143" position="2658 952" bounds="2628 941 61 23" textPosition="2628 941"> <Properties> <displayName>LDLRAP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="351" reactomeId="171056" position="2535 1001" bounds="2477 990 116 23" textPosition="2477 991" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="355" reactomeId="171082" position="2506 1104" bounds="2491 1093 30 23" textPosition="2491 1094" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="357" reactomeId="171127" position="2592 1076" bounds="2573 1065 38 23" textPosition="2573 1065" /> <org.gk.render.RenderableComplex id="359" reactomeId="8876367" position="2406 1106" bounds="2391 1095 30 23" textPosition="2391 1096" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableChemical id="362" reactomeId="1605715" position="2390 1038" bounds="2369 1023 43 31" textPosition="2373 1027" /> <org.gk.render.RenderableComplex id="363" reactomeId="8876365" position="2218 1106" bounds="2159 1095 119 23" textPosition="2168 1082" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIPA-degraded LDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="364" reactomeId="8865666" position="2234 1050" bounds="2219 1035 31 31" textPosition="2223 1039"> <Properties> <displayName>FA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="365" reactomeId="8848047" position="2308 1033" bounds="2284 1018 49 31" textPosition="2288 1022" /> <org.gk.render.RenderableProtein id="366" reactomeId="6788929" position="2339 1153" bounds="2323 1142 33 23" textPosition="2323 1142"> <Properties> <displayName>LIPA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="370" reactomeId="8876488" position="2279 995" bounds="2259 984 41 23" textPosition="2259 984"> <Properties> <displayName>NPC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="371" reactomeId="8876460" position="2332 888" bounds="2294 877 77 23" textPosition="2294 878" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NPC2:CHOL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="373" reactomeId="5216153" position="2171 876" bounds="2151 865 41 23" textPosition="2151 865"> <Properties> <displayName>NPC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="374" reactomeId="8876475" position="2171 981" bounds="2133 970 77 23" textPosition="2133 971" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NPC1:CHOL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="376" reactomeId="17957" position="1969 930" bounds="1869 871 200 118" textPosition="1868 909" bgColor="250 240 240" lineColor="255 153 102" insets="1879 883 181 97"> <Components> <Component id="378" /> <Component id="386" /> <Component id="385" /> <Component id="399" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="378" reactomeId="193384" position="2066 879" bounds="2042 864 49 31" textPosition="2046 868"> <Properties> <displayName>CHOL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="384" reactomeId="1500578" position="2090 828" bounds="2057 813 66 31" textPosition="2060 817"> <Properties> <displayName>acyl-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="385" reactomeId="8876704" position="1886 880" bounds="1859 865 55 31" textPosition="1863 869" /> <org.gk.render.RenderableEntitySet id="386" reactomeId="8876694" position="1985 880" bounds="1955 869 60 23" textPosition="1955 869"> <Properties> <displayName>SOAT1,2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="388" reactomeId="76194" position="1886 829" bounds="1857 814 59 31" textPosition="1860 818" /> <org.gk.render.RenderableCompartment id="390" reactomeId="13977" position="1877 1070" bounds="1825 1025 104 91" textPosition="1826 1038" bgColor="250 240 240" lineColor="255 153 102" insets="1833 1035 88 71"> <Properties> <displayName>lipid droplet</displayName> </Properties> <Components> <Component id="393" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="393" reactomeId="163579" position="1878 1084" bounds="1851 1069 55 31" textPosition="1855 1073" /> <org.gk.render.RenderableCompartment id="395" reactomeId="13946" position="2079 1069" bounds="2021 1025 117 88" textPosition="2016 1028" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>transport vesicle membrane</displayName> </Properties> <Components> <Component id="401" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="397" reactomeId="29356" position="1942 1137" bounds="1921 1122 43 31" textPosition="1925 1126"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="398" reactomeId="8876730" position="2011 1136" bounds="1983 1121 57 31" textPosition="1986 1125"> <Properties> <displayName>LCFA(-)</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="399" reactomeId="6813685" position="1982 988" bounds="1957 977 50 23" textPosition="1957 977"> <Properties> <displayName>NCEH1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="401" reactomeId="216762" position="2086 1085" bounds="2062 1070 49 31" textPosition="2066 1074" /> <org.gk.render.RenderableProtein id="404" reactomeId="8937441" position="1971 1219" bounds="1952 1208 38 23" textPosition="1952 1208"> <Properties> <displayName>CES3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="411" reactomeId="6784727" position="2711 1044" bounds="2688 1033 46 23" textPosition="2688 1033" /> <org.gk.render.RenderableComplex id="412" reactomeId="6784730" position="2656 1172" bounds="2617 1161 79 23" textPosition="2617 1162" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PCSK9:LDLR</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="415" reactomeId="1660541" position="2312 1332" bounds="2161 1280 303 104" textPosition="2292 1345" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>endolysosome membrane</displayName> </Properties> <Components> <Component id="424" /> <Component id="427" /> <Component id="426" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="417" reactomeId="177505" position="2656 1227" bounds="2612 1209 88 37" textPosition="2611 1210" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Clathrin:AP-2 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="418" reactomeId="6784733" position="2664 1287" bounds="2599 1269 131 37" textPosition="2599 1270" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="424" reactomeId="6784728" position="2397 1319" bounds="2332 1301 131 37" textPosition="2332 1302" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PCSK9:LDLR:Clathrin:AP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="427" reactomeId="2130671" position="2229 1318" bounds="2187 1300 84 37" textPosition="2187 1301" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Clathrin:AP2 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="431" reactomeId="70101" position="3753 1379" bounds="3617 1150 272 458" textPosition="3682 1454" bgColor="250 240 240" lineColor="255 153 102" insets="3630 1161 246 434"> <Components> <Component id="433" /> <Component id="432" /> <Component id="434" /> <Component id="437" /> <Component id="438" /> <Component id="439" /> <Component id="455" /> <Component id="458" /> <Component id="454" /> <Component id="453" /> <Component id="502" /> <Component id="503" /> <Component id="504" /> <Component id="506" /> <Component id="508" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="433" reactomeId="8858026" position="3881 1154" bounds="3858 1143 47 23" textPosition="3858 1143"> <Properties> <displayName>HDLBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="434" reactomeId="8858255" position="3705 1153" bounds="3668 1142 75 23" textPosition="3668 1143" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HDLBP:HDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="436" reactomeId="265523" position="3832 1108" bounds="3788 1097 89 23" textPosition="3788 1098" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>spherical HDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="438" reactomeId="349415" position="3881 1208" bounds="3848 1197 66 23" textPosition="3851 1191"> <Properties> <displayName>SCARB1-2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="439" reactomeId="349649" position="3882 1363" bounds="3820 1345 125 37" textPosition="3819 1346" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>spherical HDL:SR-BI complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="441" reactomeId="265523" position="3966 1244" bounds="3922 1233 89 23" textPosition="3922 1234" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="454" reactomeId="264830" position="3624 1213" bounds="3588 1202 72 23" textPosition="3588 1203" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CUBN:AMN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="455" reactomeId="264851" position="3624 1363" bounds="3566 1345 117 37" textPosition="3565 1346" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>apoA-I:CUBN:AMN complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="457" reactomeId="174720" position="3553 1251" bounds="3503 1240 101 23" textPosition="3516 1234" /> <org.gk.render.RenderableCompartment id="463" reactomeId="70101" position="3110 1315" bounds="2963 1157 295 317" textPosition="3017 1423" bgColor="250 240 240" lineColor="255 153 102" insets="2974 1169 272 294"> <Components> <Component id="466" /> <Component id="470" /> <Component id="465" /> <Component id="467" /> <Component id="468" /> <Component id="476" /> <Component id="477" /> <Component id="484" /> <Component id="481" /> <Component id="482" /> <Component id="464" /> <Component id="1012" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="464" reactomeId="161320" position="3054 1279" bounds="2986 1211 136 136" textPosition="2995 1301" bgColor="250 240 240" lineColor="255 153 102" insets="2996 1221 117 116"> <Components> <Component id="486" /> <Component id="487" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="466" reactomeId="8855136" position="3254 1421" bounds="3203 1410 102 23" textPosition="3219 1404"> <Properties> <displayName>Ub-K839-VLDLR</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.21333333333333335" relativeY="0.0" label="U" trackId="0" reactomeId="8855138" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="467" reactomeId="8855129" position="3114 1402" bounds="3074 1391 80 23" textPosition="3074 1392" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MYLIP dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="468" reactomeId="8854954" position="3101 1371" bounds="3053 1360 97 23" textPosition="3053 1360"> <Properties> <displayName>NR1H2,NR1H3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="470" reactomeId="5216079" position="3253 1305" bounds="3230 1294 46 23" textPosition="3230 1294"> <Properties> <displayName>VLDLR</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="477" reactomeId="8855118" position="3251 1195" bounds="3212 1184 79 23" textPosition="3212 1185" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VLDL:PCSK9</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="479" reactomeId="6784727" position="3314 1284" bounds="3291 1273 46 23" textPosition="3291 1273"> <Properties> <displayName>PCSK9</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="482" reactomeId="8855134" position="3051 1163" bounds="2986 1145 131 37" textPosition="2986 1146" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="484" reactomeId="177505" position="3233 1150" bounds="3189 1132 88 37" textPosition="3188 1133" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="487" reactomeId="8855135" position="3055 1274" bounds="2990 1256 131 37" textPosition="2990 1257" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>VLDL:PCSK9:Clathrin:AP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="503" reactomeId="171075" position="3711 1600" bounds="3652 1585 118 31" textPosition="3656 1589"> <Properties> <displayName>cholesterol esters</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="504" reactomeId="171057" position="3633 1602" bounds="3609 1587 48 31" textPosition="3613 1591" /> <org.gk.render.RenderableChemical id="506" reactomeId="171095" position="3788 1600" bounds="3764 1585 49 31" textPosition="3768 1589" /> <org.gk.render.RenderableChemical id="508" reactomeId="171142" position="3846 1600" bounds="3831 1585 30 31" textPosition="3835 1589" /> <org.gk.render.RenderableComplex id="509" reactomeId="349645" position="3975 1534" bounds="3932 1523 87 23" textPosition="3943 1510" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>pre-beta HDL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="512" reactomeId="6789313" position="3855 983" bounds="3819 972 72 23" textPosition="3819 973" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIPG dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="514" reactomeId="174675" position="3979 938" bounds="3955 923 49 31" textPosition="3959 927" /> <org.gk.render.RenderableChemical id="516" reactomeId="174602" position="3949 982" bounds="3924 967 51 31" textPosition="3928 971" /> <org.gk.render.RenderableChemical id="521" reactomeId="109276" position="3766 980" bounds="3745 965 43 31" textPosition="3749 969" /> <org.gk.render.RenderableChemical id="523" reactomeId="171126" position="3742 938" bounds="3718 923 48 31" textPosition="3722 927" /> <org.gk.render.RenderableEntitySet id="596" reactomeId="9733405" position="2842 1046" bounds="2791 1035 103 23" textPosition="2791 1035" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true"> <Properties> <displayName>PCSK9 inhibitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="597" reactomeId="9733426" position="2796 1150" bounds="2751 1132 91 37" textPosition="2751 1133" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>PCSK9:PCSK9 inhibitors</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="668" reactomeId="7660" position="1988 1316" bounds="1904 1268 169 96" textPosition="1929 1280" bgColor="250 240 240" lineColor="255 153 102" insets="1914 1277 150 78"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="671" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="671" reactomeId="9733427" position="1990 1318" bounds="1951 1280 78 52" textPosition="1951 1307"> <Properties> <displayName>PCSK9 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNADrug id="674" reactomeId="9733431" position="2386 1496" bounds="2341 1477 91 39" textPosition="2357 1485" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>inclisiran</displayName> </Properties> </org.gk.render.RenderableRNADrug> <org.gk.render.RenderableProteinDrug id="713" reactomeId="9735898" position="819 27" bounds="780 16 78 23" textPosition="780 16" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>evinacumab</displayName> </Properties> </org.gk.render.RenderableProteinDrug> <org.gk.render.RenderableComplex id="714" reactomeId="9735926" position="990 41" bounds="951 23 78 37" textPosition="951 24" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ANGPTL3:evinacumab</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="764" reactomeId="7660" position="2303 275" bounds="2207 219 193 112" textPosition="2295 229" bgColor="250 240 240" lineColor="255 153 102" insets="2215 226 176 98"> <Components> <Component id="767" /> <Component id="766" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="767" reactomeId="9737647" position="2274 287" bounds="2238 249 72 52" textPosition="2238 276"> <Properties> <displayName>APOB gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="768" reactomeId="9737632" position="2132 264" bounds="2076 245 112 39" textPosition="2092 253"> <Properties> <displayName>APOB mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableChemicalDrug id="823" reactomeId="9737637" position="2134 320" bounds="2090 305 89 31" textPosition="2094 309" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>mipomersen</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="824" reactomeId="9737619" position="1960 288" bounds="1918 270 84 37" textPosition="1918 271" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>APOB mRNA:mipomersen</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="875" reactomeId="9737771" position="2118 127" bounds="2074 111 89 33" textPosition="2084 108" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>MTTP:lomitapide</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemicalDrug id="1003" reactomeId="349405" position="3042 764" bounds="3002 749 81 31" textPosition="3006 753" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>torcetrapib</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableComplex id="1004" reactomeId="349410" position="3091 874" bounds="3028 856 127 37" textPosition="3028 857" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>CETP:spherical HDL:torcetrapib complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemicalDrug id="1011" reactomeId="9737774" position="2256 169" bounds="2217 154 78 31" textPosition="2221 158" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>lomitapide</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableEntitySet id="1012" reactomeId="450143" position="3184 1323" bounds="3158 1312 53 22" textPosition="3165 1305"> <Properties> <displayName>K63-Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1013" reactomeId="382539" position="3920 539" bounds="3904 524 32 31" textPosition="3908 528" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="21" reactomeId="174786" points="1267 106, 1317 106, 1398 70" position="1317 106" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2" stoichiometry="40" points="1295 67" /> <Input id="3" stoichiometry="60" points="1256 67" /> <Input id="4" points="1196 63" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Catalysts> <Catalyst id="6" points="1399 234" /> </Catalysts> <Properties> <displayName>ApoB-48 + 40 triacylglycerol + 60 phospholipid =&gt; ApoB-48:TG:PL complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="22" reactomeId="174731" points="1200 167, 1200 194, 1200 222" position="1200 194" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="7" /> </Inputs> <Properties> <displayName>Degradation of newly synthesized ApoB-48</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="174741" points="1541 99, 1609 99, 1626 99" position="1609 99" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" stoichiometry="3" points="1587 139" /> <Input id="9" points="1459 131" /> <Input id="10" stoichiometry="2" points="1540 153" /> <Input id="11" points="1493 99" /> <Input id="12" points="1499 207" /> <Input id="13" stoichiometry="100" points="1579 174" /> <Input id="14" points="1464 172" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> <Activators> <Activator id="6" points="1463 255, 1653 255, 1652 152" /> </Activators> <Properties> <displayName>ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV =&gt; nascent chylomicron</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="174587" points="1691 117, 1691 185, 1690 379" position="1691 185" lineWidth="1.0"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Activators> <Activator id="17" points="1723 185" /> </Activators> <Properties> <displayName>nascent chylomicron [endoplasmic reticulum lumen] =&gt; nascent chylomicron [extracellular]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="174660" points="1628 424, 1587 424, 1548 425" position="1587 424" lineWidth="1.0"> <Inputs> <Input id="18" points="1661 442" /> <Input id="16" points="1667 408" /> </Inputs> <Outputs> <Output id="19" points="1471 465" /> <Output id="20" points="1449 423" /> </Outputs> <Properties> <displayName>nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =&gt;spherical HDL + chylomicron</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="8866329" points="2225 83, 2296 83, 2343 57" position="2296 83" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="41" points="2115 57" /> <Input id="46" points="2179 53" /> <Input id="48" points="2227 63" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> <Catalysts> <Catalyst id="44" points="2322 105" /> </Catalysts> <Inhibitors> <Inhibitor id="875" points="2166 116" /> </Inhibitors> <Properties> <displayName>MTTP lipidates APOB-100, forming a pre-VLDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="55" reactomeId="8866308" points="2385 57, 2428 74, 2468 82" position="2428 74" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="42" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Properties> <displayName>pre-VLDL translocates from RER membrane to SER lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="57" reactomeId="8866304" points="2610 124, 2597 89, 2656 89" position="2597 89" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="56" points="2536 99" /> <Input id="58" stoichiometry="899" points="2535 126" /> <Input id="61" stoichiometry="150" points="2623 160" /> <Input id="59" stoichiometry="680" points="2581 163" /> <Input id="60" stoichiometry="459" points="2543 156" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> <Properties> <displayName>pre-VLDL binds lipids to form VLDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="66" reactomeId="8866327" points="2678 104, 2678 201, 2619 422" position="2678 201" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Properties> <displayName>VLDL translocates from SER lumen to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="8866321" points="2486 436, 2486 436, 2309 436" position="2486 436" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="67" points="2557 436" /> <Input id="69" points="2507 459" /> <Input id="70" points="2503 405" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> <Properties> <displayName>VLDL binds APOC1 and APOC4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="81" reactomeId="264758" points="3376 403, 3409 403, 3470 403" position="3409 403" lineWidth="1.0"> <Inputs> <Input id="82" /> </Inputs> <Outputs> <Output id="83" /> </Outputs> <Catalysts> <Catalyst id="84" points="3409 438" /> </Catalysts> <Inhibitors> <Inhibitor id="85" points="3408 375" /> </Inhibitors> <Properties> <displayName>BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="5682084" points="3057 214, 3093 215, 3136 215" position="3093 215" lineWidth="1.0"> <Inputs> <Input id="90" points="3024 206" /> <Input id="91" stoichiometry="12" points="3008 243" /> </Inputs> <Outputs> <Output id="92" stoichiometry="16" points="3161 243" /> <Output id="93" points="3180 206" /> </Outputs> <Catalysts> <Catalyst id="94" points="3087 245" /> </Catalysts> <Properties> <displayName>ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="5682103" points="3242 219, 3248 249, 3243 288" position="3248 249" lineWidth="1.0"> <Inputs> <Input id="93" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> <Properties> <displayName>4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="100" reactomeId="5682101" points="3341 309, 3389 309, 3428 309" position="3389 309" lineWidth="1.0"> <Inputs> <Input id="96" points="3301 309" /> <Input id="101" stoichiometry="8" points="3311 267" /> </Inputs> <Outputs> <Output id="102" stoichiometry="8" points="3480 266" /> <Output id="103" points="3460 309" /> </Outputs> <Catalysts> <Catalyst id="104" points="3388 247" /> </Catalysts> <Properties> <displayName>PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="108" reactomeId="216727" points="3541 355, 3586 354, 3614 337" position="3586 354" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="83" points="3527 389" /> <Input id="103" points="3524 331" /> </Inputs> <Outputs> <Output id="109" /> </Outputs> <Properties> <displayName>4xPALM-C-p-2S-ABCA1 tetramer binds APOA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="216723" points="3743 256, 3773 292, 3801 292" position="3773 292" lineWidth="1.0"> <Inputs> <Input id="117" points="3749 184" /> <Input id="118" points="3710 217" /> <Input id="119" points="3697 238" /> </Inputs> <Outputs> <Output id="120" points="3806 255" /> <Output id="121" points="3831 256" /> <Output id="122" points="3845 297" /> </Outputs> <Catalysts> <Catalyst id="109" points="3707 301" /> </Catalysts> <Properties> <displayName>4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="129" reactomeId="216757" points="3742 311, 3764 343, 3815 343" position="3764 343" lineWidth="1.0"> <Inputs> <Input id="130" points="3773 216" /> <Input id="119" points="3687 251" /> <Input id="118" points="3704 217" /> </Inputs> <Outputs> <Output id="121" points="3842 261" /> <Output id="134" points="3919 313" /> <Output id="120" points="3809 255" /> </Outputs> <Catalysts> <Catalyst id="109" points="3707 324" /> </Catalysts> <Properties> <displayName>4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="216756" points="3757 403, 3758 403, 3728 479" position="3758 403" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="83" stoichiometry="2" points="3577 403" /> <Input id="122" stoichiometry="10" points="3854 320" /> <Input id="134" stoichiometry="25" points="3919 316" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="349657" points="3938 375, 3939 375, 3744 479" position="3939 375" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="122" stoichiometry="9" points="3885 320" /> <Input id="134" stoichiometry="22" points="3937 328" /> <Input id="147" points="3973 364" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="152" reactomeId="6784861" points="708 151, 709 168, 710 206" position="709 168" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="153" points="775 119" /> <Input id="154" points="708 121" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> <Properties> <displayName>HSPG binds LPL dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="156" reactomeId="8857928" points="773 250, 773 291, 732 334" position="773 291" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="157" points="739 261" /> <Input id="155" points="734 235" /> </Inputs> <Outputs> <Output id="158" /> </Outputs> <Properties> <displayName>GPIHBP1 binds HSPG:LPL dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="160" reactomeId="8856525" points="929 141, 930 172, 930 213" position="930 172" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="161" points="901 120" /> <Input id="162" points="956 120" /> </Inputs> <Outputs> <Output id="163" /> </Outputs> <Properties> <displayName>ANGPTL8 binds ANGPTL3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="165" reactomeId="6784628" points="780 337, 861 313, 858 230" position="861 313" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="158" /> </Inputs> <Outputs> <Output id="157" points="744 265" /> <Output id="154" points="727 121" /> <Output id="166" stoichiometry="2" points="858 179" /> </Outputs> <Catalysts> <Catalyst id="167" points="883 354" /> </Catalysts> <Activators> <Activator id="168" points="915 311" /> <Activator id="163" points="920 242" /> </Activators> <Properties> <displayName>PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="6784676" points="739 334, 808 283, 808 257" position="808 283" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="158" /> </Inputs> <Outputs> <Output id="157" points="744 269" /> <Output id="154" points="718 121" /> <Output id="166" stoichiometry="2" points="851 179" /> </Outputs> <Catalysts> <Catalyst id="171" points="808 365" /> </Catalysts> <Activators> <Activator id="168" points="915 303" /> </Activators> <Properties> <displayName>PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="173" reactomeId="6784620" points="413 134, 413 165, 413 186" position="413 165" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="174" /> </Inputs> <Outputs> <Output id="175" points="413 244" /> <Output id="176" points="381 197" /> </Outputs> <Catalysts> <Catalyst id="177" points="486 116" /> </Catalysts> <Properties> <displayName>MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="183" reactomeId="6784648" points="308 209, 298 209, 280 209" position="298 209" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="176" /> </Inputs> <Outputs> <Output id="184" /> </Outputs> <Properties> <displayName>CREB3L3 (1-?) translocates from cytosol to nucleoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="6784622" points="154 165, 154 211, 154 297" position="154 211" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="187" /> </Inputs> <Outputs> <Output id="188" /> </Outputs> <Activators> <Activator id="184" points="188 210" /> </Activators> <Properties> <displayName>APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="190" reactomeId="6785181" points="606 312, 606 325, 588 375" position="606 325" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="191" points="606 293" /> <Input id="192" points="572 301" /> </Inputs> <Outputs> <Output id="193" /> </Outputs> <Properties> <displayName>LMF1,2 bind LIPC dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="195" reactomeId="6785178" points="589 404, 606 446, 653 446" position="606 446" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="193" /> </Inputs> <Outputs> <Output id="191" points="623 293, 651 304" /> <Output id="196" points="746 485" /> </Outputs> <Properties> <displayName>LMF1,2 transport LIPC dimer from ER lumen to extracellular region</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="198" reactomeId="6785213" points="771 549, 772 585, 772 625" position="772 585" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="199" points="798 541" /> <Input id="196" points="772 514" /> </Inputs> <Outputs> <Output id="200" /> </Outputs> <Properties> <displayName>LIPC dimer binds heparin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="201" reactomeId="5694109" points="732 698, 774 698, 815 698" position="774 698" lineWidth="1.0"> <Inputs> <Input id="202" points="691 698" /> <Input id="203" points="718 717" /> </Inputs> <Outputs> <Output id="204" points="833 717" /> <Output id="205" points="859 698" /> </Outputs> <Catalysts> <Catalyst id="200" points="773 654" /> </Catalysts> <Properties> <displayName>LIPC dimer hydrolyses TAG to DAG and FA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="207" reactomeId="174757" points="1392 438, 1208 579, 1208 636" position="1208 579" lineWidth="1.0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="208" stoichiometry="50" points="1202 687" /> <Output id="209" points="1251 637" /> <Output id="214" stoichiometry="50" points="1163 654" /> </Outputs> <Catalysts> <Catalyst id="158" points="717 377, 721 429" /> </Catalysts> <Inhibitors> <Inhibitor id="212" points="1178 592" /> </Inhibitors> <Activators> <Activator id="210" points="1183 538" /> <Activator id="211" points="1231 538" /> </Activators> <Properties> <displayName>chylomicron =&gt; TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="216" reactomeId="174690" points="1396 635, 1431 635, 1467 636" position="1431 635" lineWidth="1.0"> <Inputs> <Input id="19" points="1446 494" /> <Input id="209" points="1343 637" /> </Inputs> <Outputs> <Output id="217" points="1488 669" /> <Output id="218" points="1504 626" /> </Outputs> <Properties> <displayName>TG-depleted chylomicron + spherical HDL =&gt; chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="219" reactomeId="174739" points="1601 683, 1601 682, 1671 682" position="1601 682" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="217" points="1563 683" /> <Input id="220" points="1573 722" /> </Inputs> <Outputs> <Output id="221" /> </Outputs> <Properties> <displayName>chylomicron remnant + apoE =&gt; chylomicron remnant:apoE complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="266350" points="2924 619, 2957 619, 2994 619" position="2957 619" lineWidth="1.0"> <Inputs> <Input id="228" points="2804 620" /> <Input id="229" points="2915 658" /> </Inputs> <Outputs> <Output id="230" points="3058 641" /> <Output id="231" points="3060 594" /> </Outputs> <Inhibitors> <Inhibitor id="232" points="2957 575" /> </Inhibitors> <Properties> <displayName>CETP-mediated lipid exchange: LDL gains cholesterol ester</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="234" reactomeId="176879" points="2685 621, 2685 639, 2686 667" position="2685 639" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="235" points="2685 588" /> <Input id="228" points="2768 621" /> </Inputs> <Outputs> <Output id="236" /> </Outputs> <Properties> <displayName>apolipoprotein(a) + LDL =&gt; Lp(a)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="243" reactomeId="266082" points="3378 627, 3413 626, 3440 627" position="3413 626" lineWidth="1.0"> <Inputs> <Input id="244" points="3363 647" /> <Input id="245" points="3385 593" /> <Input id="249" points="3350 604" /> </Inputs> <Outputs> <Output id="246" points="3459 609" /> <Output id="251" points="3439 583" /> <Output id="253" points="3487 627" /> </Outputs> <Catalysts> <Catalyst id="247" points="3413 684" /> </Catalysts> <Properties> <displayName>ABCG1-mediated transport of intracellular cholesterol to the cell surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="266089" points="3638 643, 3639 673, 3638 714" position="3639 673" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="136" points="3717 508" /> <Input id="253" points="3542 630" /> </Inputs> <Outputs> <Output id="256" /> </Outputs> <Properties> <displayName>Discoidal HDL binds membrane-associated free cholesterol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="258" reactomeId="264678" points="3743 612, 3743 645, 3758 719" position="3743 645" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="259" points="3784 612" /> <Input id="136" points="3725 508" /> </Inputs> <Outputs> <Output id="260" /> </Outputs> <Properties> <displayName>LCAT + discoidal HDL &lt;=&gt; LCAT:discoidal HDL complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="264689" points="3762 719, 3764 648, 3768 627" position="3764 648" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="260" /> </Inputs> <Outputs> <Output id="259" points="3784 620" /> <Output id="136" points="3727 508" /> </Outputs> <Properties> <displayName>LCAT:discoidal HDL complex &lt;=&gt; LCAT + discoidal HDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="263" reactomeId="266303" points="3430 809, 3431 856, 3430 908" position="3431 856" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="265" points="3465 767" /> <Input id="266" points="3405 799" /> <Input id="267" points="3398 828" /> <Input id="269" points="3366 812" /> </Inputs> <Outputs> <Output id="271" /> </Outputs> <Properties> <displayName>Spherical HDL binds C and E apolipoproteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="272" reactomeId="266299" points="3555 753, 3602 822, 3627 858" position="3602 822" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="265" points="3523 752" /> <Input id="253" stoichiometry="2" points="3519 646" /> <Input id="276" stoichiometry="2" points="3515 709" /> </Inputs> <Outputs> <Output id="273" /> </Outputs> <Activators> <Activator id="274" points="3636 797" /> </Activators> <Properties> <displayName>Spherical HDL binds membrane-associated free cholesterol and phospholipids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="277" reactomeId="264695" points="3877 584, 3877 614, 3878 656" position="3877 614" lineWidth="1.0"> <Inputs> <Input id="1013" points="3905 558" /> <Input id="278" points="3852 557" /> </Inputs> <Outputs> <Output id="280" points="3902 662" /> <Output id="281" points="3878 697" /> </Outputs> <Catalysts> <Catalyst id="259" points="3829 613" /> </Catalysts> <Activators> <Activator id="284" points="3903 614" /> </Activators> <Properties> <displayName>cholesterol + phosphatidylcholine (lecithin) =&gt; cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="286" reactomeId="264679" points="3943 748, 3943 777, 3943 814" position="3943 777" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="287" points="3978 735" /> <Input id="280" stoichiometry="2" points="3943 690" /> </Inputs> <Outputs> <Output id="288" /> </Outputs> <Properties> <displayName>Serum albumin binds 2-lysophosphatidylcholine</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="289" reactomeId="266315" points="3549 846, 3549 884, 3565 949" position="3549 884" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="265" points="3484 767" /> <Input id="291" points="3513 841" /> </Inputs> <Outputs> <Output id="290" /> </Outputs> <Properties> <displayName>LCAT + spherical HDL &lt;=&gt; LCAT:spherical HDL complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="292" reactomeId="266310" points="3570 949, 3570 882, 3569 820" position="3570 882" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="290" /> </Inputs> <Outputs> <Output id="291" points="3513 834" /> <Output id="265" points="3490 767" /> </Outputs> <Properties> <displayName>LCAT:spherical HDL complex &lt;=&gt; LCAT + spherical HDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="294" reactomeId="266328" points="2983 729, 2983 729, 2983 730" position="2983 729" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="230" points="3072 670" /> <Input id="265" points="3428 749" /> </Inputs> <Outputs> <Output id="295" points="2952 749" /> <Output id="229" points="2937 701" /> </Outputs> <Properties> <displayName>CETP-mediated lipid exchange: spherical HDL gains triacylglycerol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="305" reactomeId="174657" points="1672 812, 1673 851, 1659 854" position="1673 851" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="306" points="1617 805" /> <Input id="221" points="1711 711" /> </Inputs> <Outputs> <Output id="307" /> </Outputs> <Activators> <Activator id="308" points="1702 879" /> </Activators> <Properties> <displayName>chylomicron remnant:apoE complex + LDLR =&gt; chylomicron remnant:apoE:LDLR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="309" reactomeId="174706" points="1598 911, 1599 957, 1546 956" position="1599 957" lineWidth="1.0"> <Inputs> <Input id="307" /> </Inputs> <Outputs> <Output id="310" /> </Outputs> <Activators> <Activator id="311" points="1599 990" /> </Activators> <Properties> <displayName>chylomicron remnant:apoE:LDLR complex [plasma membrane] =&gt; chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="312" reactomeId="174808" points="1479 985, 1480 1008, 1479 1036" position="1480 1008" lineWidth="1.0"> <Inputs> <Input id="310" /> </Inputs> <Outputs> <Output id="313" /> </Outputs> <Properties> <displayName>chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] =&gt; chylomicron remnant:apoE:LDLR complex [endosome membrane]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="315" reactomeId="174624" points="1479 1093, 1479 1122, 1479 1147" position="1479 1122" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="313" /> </Inputs> <Outputs> <Output id="316" points="1529 1153" /> <Output id="317" points="1479 1166" /> </Outputs> <Properties> <displayName>chylomicron remnant:apoE:LDLR complex =&gt; chylomicron remnant:apoE + LDLR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="319" reactomeId="8854462" points="1921 537, 1950 536, 1978 536" position="1950 536" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="320" points="1890 534" /> <Input id="71" points="2265 441" /> </Inputs> <Outputs> <Output id="321" /> </Outputs> <Properties> <displayName>VLDLR binds VLDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="322" reactomeId="8854408" points="2199 537, 2200 537, 2237 537" position="2200 537" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="323" points="2167 537" /> <Input id="71" points="2276 451" /> </Inputs> <Outputs> <Output id="324" /> </Outputs> <Properties> <displayName>APOBR dimer binds VLDLs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="326" reactomeId="8933292" points="2449 536, 2480 535, 2496 535" position="2480 535" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="327" points="2423 536" /> <Input id="71" points="2309 447" /> </Inputs> <Outputs> <Output id="328" /> </Outputs> <Properties> <displayName>LSR trimer binds VLDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="334" reactomeId="8933258" points="2512 759, 2492 794, 2466 794" position="2492 794" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="228" points="2777 636, 2687 759" /> <Input id="336" points="2550 780" /> </Inputs> <Outputs> <Output id="335" /> </Outputs> <Properties> <displayName>LSR trimer binds LDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="337" reactomeId="171122" points="2783 930, 2725 880, 2671 837" position="2725 880" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="228" points="2785 636" /> <Input id="340" points="2675 995" /> </Inputs> <Outputs> <Output id="338" /> </Outputs> <Properties> <displayName>LDL + LDLR =&gt; LDL:LDLR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="346" reactomeId="171141" points="2657 837, 2657 901, 2649 901" position="2657 901" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="338" /> </Inputs> <Outputs> <Output id="347" /> </Outputs> <Activators> <Activator id="349" points="2657 938" /> </Activators> <Properties> <displayName>LDL:LDLR complex [plasma membrane] =&gt; LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="350" reactomeId="171059" points="2573 918, 2535 946, 2535 987" position="2535 946" lineWidth="1.0"> <Inputs> <Input id="347" /> </Inputs> <Outputs> <Output id="351" /> </Outputs> <Properties> <displayName>LDLR:LDL complex [coated vesicle membrane] =&gt; LDLR:LDL complex [endosome membrane]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="354" reactomeId="171106" points="2535 1016, 2536 1047, 2536 1075" position="2536 1047" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="351" /> </Inputs> <Outputs> <Output id="355" points="2517 1090" /> <Output id="357" points="2570 1075" /> </Outputs> <Properties> <displayName>LDLR:LDL complex =&gt; LDLR + LDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="358" reactomeId="8876366" points="2488 1104, 2456 1105, 2424 1105" position="2456 1105" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="355" /> </Inputs> <Outputs> <Output id="359" /> </Outputs> <Properties> <displayName>LDL translocates from endosome lumen to lysosome lumen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="361" reactomeId="8865667" points="2368 1105, 2335 1104, 2296 1104" position="2335 1104" lineWidth="1.0"> <Inputs> <Input id="359" points="2388 1105" /> <Input id="362" points="2384 1057" /> </Inputs> <Outputs> <Output id="365" stoichiometry="1500" points="2305 1052" /> <Output id="363" points="2281 1104" /> <Output id="364" stoichiometry="1500" points="2253 1063" /> </Outputs> <Catalysts> <Catalyst id="366" points="2338 1139" /> </Catalysts> <Properties> <displayName>LIPA hydrolyses sterol esters to sterols and fatty acids</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="369" reactomeId="8876472" points="2333 975, 2333 947, 2332 903" position="2333 947" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="370" points="2303 987" /> <Input id="365" points="2314 1015" /> </Inputs> <Outputs> <Output id="371" /> </Outputs> <Properties> <displayName>NPC2 binds CHOL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="372" reactomeId="8876484" points="2246 898, 2246 921, 2246 959" position="2246 921" lineWidth="1.0"> <Inputs> <Input id="371" points="2291 892" /> <Input id="373" points="2195 882" /> </Inputs> <Outputs> <Output id="374" points="2210 967" /> <Output id="370" points="2268 981" /> </Outputs> <Properties> <displayName>NPC2 transfers CHOL to NPC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="377" reactomeId="8876485" points="2158 967, 2130 942, 2130 907" position="2130 942" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="374" /> </Inputs> <Outputs> <Output id="373" points="2155 891" /> <Output id="378" points="2094 889" /> </Outputs> <Properties> <displayName>CHOL translocates from lysosome membrane to ER membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="383" reactomeId="8876696" points="2016 828, 1985 828, 1952 829" position="1985 828" lineWidth="1.0"> <Inputs> <Input id="384" points="2054 828" /> <Input id="378" points="2050 861" /> </Inputs> <Outputs> <Output id="385" points="1906 862" /> <Output id="388" points="1919 829" /> </Outputs> <Catalysts> <Catalyst id="386" points="1985 863" /> </Catalysts> <Properties> <displayName>SOAT1,2 transfer acyl group to CHOL forming CHEST</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="392" reactomeId="8876731" points="1856 879, 1820 879, 1873 1066" position="1820 879" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="385" /> </Inputs> <Outputs> <Output id="393" /> </Outputs> <Properties> <displayName>CHEST translocates from ER membrane to lipid particle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="396" reactomeId="6813720" points="1962 1084, 1981 1084, 2006 1084" position="1981 1084" lineWidth="1.0"> <Inputs> <Input id="393" points="1909 1084" /> <Input id="397" points="1947 1119" /> </Inputs> <Outputs> <Output id="398" points="2009 1118" /> <Output id="401" points="2059 1084" /> </Outputs> <Catalysts> <Catalyst id="399" points="1981 1003" /> </Catalysts> <Properties> <displayName>NCEH1 hydrolyzes cholesterol esters</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="402" reactomeId="8937442" points="1921 1173, 1971 1173, 2043 1174" position="1971 1173" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="393" points="1885 1103" /> <Input id="397" points="1932 1156" /> </Inputs> <Outputs> <Output id="398" points="2024 1155" /> <Output id="401" points="2078 1104" /> </Outputs> <Catalysts> <Catalyst id="404" points="1971 1205" /> </Catalysts> <Properties> <displayName>CES3 hydrolyses CHEST to CHOL and LCFA(-)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="409" reactomeId="171087" points="2602 1062, 2620 1046, 2645 1024" position="2620 1046" lineWidth="1.0"> <Inputs> <Input id="357" /> </Inputs> <Outputs> <Output id="340" /> </Outputs> <Properties> <displayName>LDLR [endosome membrane] =&gt; LDLR [plasma membrane]</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="410" reactomeId="6784734" points="2657 1056, 2656 1097, 2656 1158" position="2656 1097" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="411" points="2685 1049" /> <Input id="340" points="2657 1024" /> </Inputs> <Outputs> <Output id="412" /> </Outputs> <Properties> <displayName>PCSK9 binds LDLR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="416" reactomeId="6784735" points="2582 1215, 2583 1255, 2617 1266" position="2583 1255" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="412" points="2636 1187" /> <Input id="417" points="2609 1219" /> </Inputs> <Outputs> <Output id="418" /> </Outputs> <Properties> <displayName>PCSK9:LDLR bind to Clathrin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="423" reactomeId="6784729" points="2596 1295, 2537 1303, 2466 1311" position="2537 1303" lineWidth="1.0"> <Inputs> <Input id="418" /> </Inputs> <Outputs> <Output id="424" /> </Outputs> <Properties> <displayName>PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="426" reactomeId="6784738" points="2329 1318, 2316 1318, 2274 1318" position="2316 1318" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="424" /> </Inputs> <Outputs> <Output id="427" /> </Outputs> <Properties> <displayName>Degradation of PCSK9:LDLR:Clathrin-coated vesicle</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="432" reactomeId="8858252" points="3808 1153, 3775 1153, 3746 1153" position="3775 1153" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="433" points="3855 1153" /> <Input id="436" points="3825 1123" /> </Inputs> <Outputs> <Output id="434" /> </Outputs> <Properties> <displayName>HDLBP binds HDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="437" reactomeId="349637" points="3881 1266, 3880 1295, 3881 1342" position="3880 1295" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="438" points="3881 1223" /> <Input id="441" points="3919 1255" /> </Inputs> <Outputs> <Output id="439" /> </Outputs> <Properties> <displayName>spherical HDL and SR-BI receptor form a complex at the cell surface</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="453" reactomeId="264848" points="3623 1272, 3623 1303, 3623 1342" position="3623 1303" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="454" points="3623 1228" /> <Input id="457" points="3591 1266" /> </Inputs> <Outputs> <Output id="455" /> </Outputs> <Properties> <displayName>apoA-I binds to CUBN:AMN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="458" reactomeId="264834" points="3650 1385, 3689 1408, 3731 1432" position="3689 1408" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="455" /> </Inputs> <Properties> <displayName>Endocytosis and degradation of apoA-I</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="465" reactomeId="8854628" points="3253 1344, 3254 1358, 3254 1407" position="3254 1358" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1012" stoichiometry="3" points="3217 1331" /> <Input id="470" points="3253 1320" /> </Inputs> <Outputs> <Output id="466" /> </Outputs> <Catalysts> <Catalyst id="467" points="3150 1388" /> </Catalysts> <Activators> <Activator id="468" points="3156 1366" /> </Activators> <Properties> <displayName>MYLIP dimer ubiquitinates VLDLR on Lys-839</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="476" reactomeId="8855111" points="3251 1268, 3251 1245, 3251 1210" position="3251 1245" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="479" points="3288 1278" /> <Input id="470" points="3252 1291" /> </Inputs> <Outputs> <Output id="477" /> </Outputs> <Properties> <displayName>VLDLR binds PCSK9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="481" reactomeId="8855131" points="3159 1164, 3124 1163, 3120 1163" position="3124 1163" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="477" points="3216 1181" /> <Input id="484" points="3186 1158" /> </Inputs> <Outputs> <Output id="482" /> </Outputs> <Properties> <displayName>VLDLR:PCSK9 binds Clathrin-coated vesicles</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="486" reactomeId="8855130" points="3051 1185, 3051 1214, 3053 1253" position="3051 1214" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="482" /> </Inputs> <Outputs> <Output id="487" /> </Outputs> <Properties> <displayName>VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="502" reactomeId="349638" points="3882 1385, 3882 1417, 3882 1449, 3798 1480" position="3882 1417" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="439" /> </Inputs> <Outputs> <Output id="504" stoichiometry="20" points="3653 1584" /> <Output id="503" stoichiometry="156" points="3722 1582" /> <Output id="438" points="3869 1223, 3796 1294" /> <Output id="509" stoichiometry="2" points="3937 1520" /> <Output id="508" stoichiometry="134" points="3839 1582" /> <Output id="506" stoichiometry="38" points="3789 1582" /> </Outputs> <Properties> <displayName>Disassembly of SR-BI-bound spherical HDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="510" reactomeId="8980228" points="3804 937, 3856 937, 3901 937" position="3856 937" lineWidth="1.0"> <Inputs> <Input id="521" points="3779 962" /> <Input id="523" points="3769 937" /> </Inputs> <Outputs> <Output id="514" points="3952 937" /> <Output id="516" points="3932 964" /> </Outputs> <Catalysts> <Catalyst id="512" points="3855 969" /> </Catalysts> <Properties> <displayName>LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="595" reactomeId="9733403" points="2796 1085, 2796 1086, 2796 1129" position="2796 1086" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="596" points="2828 1064" /> <Input id="411" points="2737 1055" /> </Inputs> <Outputs> <Output id="597" /> </Outputs> <Properties> <displayName>PCSK9 binds PCSK9 inhibitors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="670" reactomeId="9733406" points="2038 1282, 2187 1442, 2385 1442, 2762 1442, 2712 1059" position="2385 1442" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="671" /> </Inputs> <Outputs> <Output id="411" /> </Outputs> <Inhibitors> <Inhibitor id="674" points="2385 1482" /> </Inhibitors> <Properties> <displayName>PCSK9 gene expression</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="712" reactomeId="9735929" points="888 63, 888 63, 948 49" position="888 63" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="161" points="888 91" /> <Input id="713" points="841 42" /> </Inputs> <Outputs> <Output id="714" /> </Outputs> <Properties> <displayName>ANGPTL3 binds evinacumab</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="766" reactomeId="9737662" points="2319 251, 2211 263, 2191 263" position="2211 263" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="767" /> </Inputs> <Outputs> <Output id="768" /> </Outputs> <Properties> <displayName>APOB gene transcribes APOB mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="788" reactomeId="9737631" points="2087 250, 1967 192, 1967 80, 2040 57" position="1967 192" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="768" /> </Inputs> <Outputs> <Output id="41" /> </Outputs> <Properties> <displayName>APOB mRNA is translated into APOB protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="822" reactomeId="9737634" points="2047 288, 2045 288, 2005 288" position="2045 288" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="823" points="2091 302" /> <Input id="768" points="2073 279" /> </Inputs> <Outputs> <Output id="824" /> </Outputs> <Properties> <displayName>APOB mRNA binds mipomersen</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="873" reactomeId="9737780" points="2239 126, 2166 126" position="2166 126" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1011" points="2249 151" /> <Input id="44" points="2290 126" /> </Inputs> <Outputs> <Output id="875" /> </Outputs> <Properties> <displayName>MTTP binds lomitapide</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1002" reactomeId="349404" points="3089 801, 3090 802, 3090 853" position="3090 802" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1003" points="3061 783" /> <Input id="230" points="3089 670" /> <Input id="265" points="3428 757" /> </Inputs> <Outputs> <Output id="1004" /> </Outputs> <Properties> <displayName>CETP + spherical HDL + torcetrapib =&gt; CETP:spherical HDL:torcetrapib complex</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Plasma lipoprotein assembly, remodeling, and clearance and Defective ABCA1 causes TGD (8964196)
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