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Details on Person GNB1:GNG2 binds ARHGEF18

Class:Id	Reaction:8964156
_displayName	GNB1:GNG2 binds ARHGEF18
_doRelease	FALSE
_timestamp	2017-02-15 19:44:39
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8964154] Orlic-Milacic, Marija, 2017-02-15
input	[Complex:8964146] GNB1:GNG2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:195104] ARHGEF18 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8964157] G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production [LiteratureReference:8964153] Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor
name	GNB1:GNG2 binds ARHGEF18
output	[Complex:8964147] GNB1:GNG2:ARHGEF18 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:825631] Glucagon:GCGR mediates GTP-GDP exchange [Homo sapiens] [Reaction:163625] Glucagon binds to Glucagon receptor [Homo sapiens] [Reaction:400037] Gi,Go Heterotrimeric G-protein complex dissociates [Homo sapiens] [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins [Homo sapiens] [Reaction:422320] Heterotrimeric G(s) complex dissociates [Homo sapiens] [Reaction:432195] AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP [Homo sapiens] [Reaction:381706] GLP1R:GLP1 activates G(s) [Homo sapiens] [Reaction:392202] Dissociation of the P2Y purinoceptor 12:Gi complex [Homo sapiens] [Reaction:392195] Gi activation by P2Y purinoceptor 12 [Homo sapiens] [Reaction:418576] Dissociation of the P2Y purinoceptor 1:Gq complex [Homo sapiens] [Reaction:418579] Gq activation by P2Y purinoceptor 1 [Homo sapiens] [Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens] [Reaction:114552] Thrombin-activated PARs activate G12/13 [Homo sapiens] [Reaction:397835] Thrombin-activated PARs:Gq (active) dissociate [Homo sapiens] [Reaction:114558] Thrombin-activated PARs activate Gq [Homo sapiens] [Reaction:392874] Dissociation of the Prostacyclin receptor:Gs complex [Homo sapiens] [Reaction:392870] Gs activation by prostacyclin receptor [Homo sapiens] [Reaction:428918] Dissociation of the TP:G13 complex [Homo sapiens] [Reaction:428917] G13 activation by TP receptor [Homo sapiens] [Reaction:428752] Dissociation of the TP:Gq complex [Homo sapiens] [Reaction:428750] Gq activation by TP receptor [Homo sapiens] [Reaction:3965447] G-protein subunits dissociate from WNT:FZD complex [Homo sapiens] [Reaction:3965444] WNT:FZD complex promotes G-protein nucleotide exchange [Homo sapiens] [Reaction:420883] Opsins act as GEFs for G alpha-t [Homo sapiens] [Reaction:8982637] Opsins binds G alpha-t [Homo sapiens] [Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens] [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 [Homo sapiens] [Reaction:749454] The Ligand:GPCR:Gi complex dissociates [Homo sapiens] [Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens] [Reaction:749452] The Ligand:GPCR:Gq complex dissociates [Homo sapiens] [Reaction:379048] Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 [Homo sapiens] [Reaction:744886] The Ligand:GPCR:Gs complex dissociates [Homo sapiens] [Reaction:379044] Liganded Gs-activating GPCR acts as a GEF for Gs [Homo sapiens] [Reaction:751024] The Ligand:GPCR:Gz complex dissociates [Homo sapiens] [Reaction:749453] Liganded Gz-activating GPCR acts as a GEF for Gz [Homo sapiens] [Reaction:112271] The receptor:G-protein complex dissociates [Homo sapiens] [Reaction:167429] The receptor:G-protein complex binds GTP [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8964162] R-HSA-8964156.1
summation	[Summation:8964149] The heterodimer of G-protein beta1 and G-protein gamma2 (GNB...
(hasEvent)	[Pathway:8964133] ARHGEF18 activates RHOA [Homo sapiens] [Pathway:8964137] Activation of RAC1 [Homo sapiens] [Pathway:8964191] Activation of RAC1 in RHOA placeholder [Homo sapiens]
(precedingEvent)	[Reaction:8964172] ARHGEF18 exchanges GDP for GTP on RHOA [Homo sapiens] [Reaction:8964190] ARHGEF18 exchanges GDP for GTP on RAC1 [Homo sapiens]
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No pathways have been reviewed or authored by GNB1:GNG2 binds ARHGEF18 (8964156)