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Details on Person DHFR gene expression is stimulated by E2F1

Class:Id	BlackBoxEvent:8961874
_displayName	DHFR gene expression is stimulated by E2F1
_doRelease	TRUE
_timestamp	2017-02-28 16:48:29
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961876] Orlic-Milacic, Marija, 2017-02-06
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:8954061] DHFR gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961868] Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1 [LiteratureReference:8961854] Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DHFR gene expression is stimulated by E2F1
output	[EntityWithAccessionedSequence:197984] DHFR [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8961863] E2F1 binds the DHFR gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8961875] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]'
regulationReference	[RegulationReference:9642682] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961878] R-HSA-8961874.4
summation	[Summation:8961873] E2F1 directly stimulates transcription of the DHFR gene, enc...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
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No pathways have been reviewed or authored by DHFR gene expression is stimulated by E2F1 (8961874)