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Details on Person E2F1 binds the DHFR gene promoter

Class:Id	Reaction:8961863
_displayName	E2F1 binds the DHFR gene promoter
_doRelease	TRUE
_timestamp	2017-02-28 16:48:30
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961867] Orlic-Milacic, Marija, 2017-02-06
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[Complex:68653] E2F1:TFDP1,TFDP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8954061] DHFR gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961868] Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1 [LiteratureReference:8961854] Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds the DHFR gene promoter
output	[Complex:8961860] E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961871] R-HSA-8961863.2
summation	[Summation:8961862] E2F1 binds to E2F binding sites in the promoter of the DHFR ...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8961874] DHFR gene expression is stimulated by E2F1 [Homo sapiens]
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No pathways have been reviewed or authored by E2F1 binds the DHFR gene promoter (8961863)