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Details on Person ORC1 gene expression is stimulated by E2F1

Class:Id	BlackBoxEvent:8961678
_displayName	ORC1 gene expression is stimulated by E2F1
_doRelease	TRUE
_timestamp	2017-02-28 16:48:31
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961680] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:2888958] ORC1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. [LiteratureReference:113660] Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor [LiteratureReference:113659] E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
modified	[InstanceEdit:8961685] Orlic-Milacic, Marija, 2017-02-03 [InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ORC1 gene expression is stimulated by E2F1
output	[EntityWithAccessionedSequence:68522] ORC1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8961671] E2F1 binds the ORC1 gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8961682] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641716] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm]' Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961681] R-HSA-8961678.4
summation	[Summation:8961679] E2F1 directly stimulates transcription of the ORC1 gene (Oht...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
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No pathways have been reviewed or authored by ORC1 gene expression is stimulated by E2F1 (8961678)