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Details on Person E2F1 binds the ORC1 gene promoter

Class:Id	Reaction:8961671
_displayName	E2F1 binds the ORC1 gene promoter
_doRelease	TRUE
_timestamp	2017-02-28 16:48:30
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961673] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[Complex:68653] E2F1:TFDP1,TFDP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2888958] ORC1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. [LiteratureReference:113660] Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds the ORC1 gene promoter
output	[Complex:8961672] E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961675] R-HSA-8961671.2
summation	[Summation:8961670] E2F1 binds to E2F binding sites in the promoter of the ORC1 ...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8961678] ORC1 gene expression is stimulated by E2F1 [Homo sapiens]
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No pathways have been reviewed or authored by E2F1 binds the ORC1 gene promoter (8961671)