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Details on Person PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

Class:Id	BlackBoxEvent:8961665
_displayName	PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex
_doRelease	TRUE
_timestamp	2017-02-28 16:48:31
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961666] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:8961653] PCNA gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961656] An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene [LiteratureReference:113623] Developmental control of a G1-S transcriptional program in Drosophila
modified	[InstanceEdit:8964521] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:8964528] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex
output	[EntityWithAccessionedSequence:68439] PCNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8961651] E2F1 binds the PCNA gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8964465] DREAM complex binds the PCNA gene promoter [Homo sapiens] [Reaction:1362261] p130 (RBL2) associates with MuvB to form DREAM complex [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8961663] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8964518] Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]'
regulationReference	[RegulationReference:9641787] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [RegulationReference:9642359] Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21 [InstanceEdit:1538129] MacPherson, D, 2011-08-25
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961668] R-HSA-8961665.4
summation	[Summation:8961664] E2F1 directly stimulates transcription of the PCNA gene, whi...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens] [Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex [Homo sapiens]
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No pathways have been reviewed or authored by PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (8961665)