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Details on Person POLA1 gene transcription is stimulated by E2F1

Class:Id	BlackBoxEvent:8961632
_displayName	POLA1 gene transcription is stimulated by E2F1
_doRelease	TRUE
_timestamp	2017-02-28 16:48:32
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961642] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:8961640] POLA1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961637] Combinatorial gene control involving E2F and E Box family members [LiteratureReference:113629] Functional properties of a Drosophila homolog of the E2F1 gene
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	POLA1 gene transcription is stimulated by E2F1
output	[EntityWithAccessionedSequence:68487] POLA1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8961636] E2F1 binds the POLA1 gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:8961638] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641309] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961644] R-HSA-8961632.4
summation	[Summation:8961643] E2F1 binds to E2F binding sites in the promoter of the POLA1...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
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No pathways have been reviewed or authored by POLA1 gene transcription is stimulated by E2F1 (8961632)