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Details on Person E2F1 binds the CDC6 gene promoter

Class:Id	Reaction:8961620
_displayName	E2F1 binds the CDC6 gene promoter
_doRelease	TRUE
_timestamp	2017-02-28 16:48:30
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961623] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[Complex:68653] E2F1:TFDP1,TFDP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8961618] CDC6 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:68682] Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells [LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.
modified	[InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E2F1 binds the CDC6 gene promoter
output	[Complex:8961621] E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961627] R-HSA-8961620.2
summation	[Summation:8961622] E2F1 binds to E2F binding sites in the promoter of the CDC6 ...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8961619] CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex [Homo sapiens]
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No pathways have been reviewed or authored by E2F1 binds the CDC6 gene promoter (8961620)