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Details on Person CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex

Class:Id	BlackBoxEvent:8961619
_displayName	CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
_doRelease	TRUE
_timestamp	2017-02-28 16:48:29
authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961623] Orlic-Milacic, Marija, 2017-02-03
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
input	[EntityWithAccessionedSequence:8961618] CDC6 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:68682] Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells [LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. [LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
modified	[InstanceEdit:8964510] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:8964528] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:8980637] Orlic-Milacic, Marija, 2017-02-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
output	[EntityWithAccessionedSequence:68542] CDC6 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8961620] E2F1 binds the CDC6 gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8964498] DREAM complex binds the CDC6 gene promoter [Homo sapiens] [Reaction:1362261] p130 (RBL2) associates with MuvB to form DREAM complex [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:539112] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8964507] Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641835] Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2009-09-30
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21 [InstanceEdit:1538129] MacPherson, D, 2011-08-25
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8961628] R-HSA-8961619.4
summation	[Summation:8961617] E2F1 directly stimulates transcription of the CDC6 gene (Yan...
(hasEvent)	[Pathway:69205] G1/S-Specific Transcription [Homo sapiens] [Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex [Homo sapiens]
(precedingEvent)	[Reaction:68688] CDC6 association with ORC(1-6) at replication origins [Homo sapiens] [Reaction:9749220] CDC6 binds ORC(1-6) [Homo sapiens]
(replacementInstances)	[_Deleted:9768312] Deletion of instance: 68637
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No pathways have been reviewed or authored by CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (8961619)