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Details on Person SLC30A10 transports Mn2+ from cytosol to extracellular region

Class:Id	Reaction:8959798
_displayName	SLC30A10 transports Mn2+ from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2025-08-13 17:17:45
authored	[InstanceEdit:8959797] Jassal, Bijay, 2017-01-31
catalystActivity	[CatalystActivity:8959817] manganese ion transmembrane transporter activity of SLC30A10 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8959797] Jassal, Bijay, 2017-01-31
crossReference	[DatabaseIdentifier:9957276] RHEA:73061
edited	[InstanceEdit:8959797] Jassal, Bijay, 2017-01-31
input	[SimpleEntity:29418] Mn2+ [cytosol] [SimpleEntity:74112] Ca2+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8959832] Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man [LiteratureReference:8959837] Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease [LiteratureReference:8959827] SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity [LiteratureReference:9957284] Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn²⁺ is driven by an active Ca²⁺-coupled exchange
modified	[InstanceEdit:8959831] Jassal, Bijay, 2017-01-31 [InstanceEdit:8961787] Jassal, Bijay, 2017-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9957283] Stephan, Ralf, 2025-06-18 [InstanceEdit:9963146] Stephan, Ralf, 2025-08-13
name	SLC30A10 transports Mn2+ from cytosol to extracellular region
output	[SimpleEntity:266099] Mn2+ [extracellular region] [SimpleEntity:74016] Ca2+ [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8961788] D'Eustachio, Peter, 2017-02-06 [InstanceEdit:9962967] D'Eustachio, Peter, 2025-08-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8959799] R-HSA-8959798.3
structureModified	[InstanceEdit:9957283] Stephan, Ralf, 2025-06-18
summation	[Summation:8959805] Manganese (Mn2+) is an essential metal that functions as a c...
(hasEvent)	[Pathway:425410] Metal ion SLC transporters [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964760] Update Tracker - [Reaction:8959798] SLC30A10 transports Mn2+ from cytosol to extracellular region - v94:[modifyText, removeInput, removeLiteratureReference, removeOutput]
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