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Details on Person SEPHS2 phosphorylates H2Se to form SELP

Class:Id	Reaction:8959510
_displayName	SEPHS2 phosphorylates H2Se to form SELP
_doRelease	TRUE
_timestamp	2025-02-25 22:17:33
authored	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
catalystActivity	[CatalystActivity:8959517] selenide, water dikinase activity of SEPHS2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
crossReference	[DatabaseIdentifier:9930604] RHEA:18738
edited	[InstanceEdit:8959515] Jassal, Bijay, 2017-01-26
input	[SimpleEntity:5357660] selanide [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:8959509] Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation
modified	[InstanceEdit:8959522] Jassal, Bijay, 2017-01-26 [InstanceEdit:8959645] Jassal, Bijay, 2017-01-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	SEPHS2 phosphorylates H2Se to form SELP ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate
output	[SimpleEntity:8959518] SELP [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:2408500] GSSeH condenses with GSH to form H2Se and GSSG [Homo sapiens] [Reaction:2408542] GSSeSG is reduced to GSSeH and GSH by GSR [Homo sapiens] [BlackBoxEvent:5333608] GSSebGalNac is reduced and methylated to MeSebGalNac [Homo sapiens] [Reaction:2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase [Homo sapiens] [Reaction:2408537] Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH [Homo sapiens] [Reaction:2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH [Homo sapiens] [Reaction:2408536] H2Se is methylated to MeSeH by H2Se methyltransferase [Homo sapiens] [Reaction:5263614] MeSeOH is reduced to MeSeH by TXNRD1 [Homo sapiens] [BlackBoxEvent:5333609] MeSebGalNac is hydrolysed to MeSeH and bGalNac [Homo sapiens] [Reaction:2408558] SeO3(2-) is reduced to H2Se by TXNRD1 [Homo sapiens] [Reaction:2408548] PAPSe is reduced to SeO3(2-) by PAPSe reductase [Homo sapiens] [Reaction:2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer [Homo sapiens] [Reaction:2408543] SeCysta is hydrolysed to Sec by PXLP-K212-CTH [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8959521] R-HSA-8959510.3
structureModified	[InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
summation	[Summation:8959523] Selenoproteins are proteins that incorporate the nonstandard...
(hasEvent)	[Pathway:2408557] Selenocysteine synthesis [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)	[Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer [Homo sapiens]
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