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Details on Person UniProt:Q9WV92 Epb41l3
| Class:Id | ReferenceGeneProduct:89582 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:1-929 added on Fri February 6 2015;chain:2-929 added on Fri February 6 2015;initiator methionine:1 for 89582 removed on Fri Nov 03 2023;initiator methionine: for 89582 added on Fri Nov 03 2023;initiator methionine: for 89582 removed on Fri Aug 15 2025;initiator methionine:1 for 89582 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9WV92 Epb41l3 |
| _timestamp | 2025-08-15 21:22:15 |
| chain | chain:1-929 initiator methionine:1 chain:2-929 |
| checksum | F4975FF405DA44AE |
| comment | FUNCTION Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5 (By similarity).SUBUNIT Interacts (via FERM domain) with CADM1. Interacts (via FERM domain) with PRMT3; the interaction is direct and inhibits the protein-arginine N-methyltransferase activity of PRMT3. Interacts with PRMT5. Interacts with PRMT6.SUBUNIT Has the complete spectrin--actin-binding (SAB) domain and fully interacts with spectrin and actin.SUBCELLULAR LOCATION Detected in the cytoplasm of actively dividing cells.ALTERNATIVE PRODUCTS Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Detected in brain (at protein level). Highest expression in brain, lower in testis, adrenal gland, heart and kidney. Also present in muscle and epithelial cells. Isoform 1 is expressed in brain, isoform 2 is expressed in heart and isoform 3 is mostly expressed in kidney but also in heart and brain. Isoform 6 seems to be most abundant in kidney while isoform 4 and isoform 5 are predominantly expressed in heart and brain.MISCELLANEOUS The complete SAB domain is present only in the heart-specific isoforms (isoform 2 and isoform 5).MISCELLANEOUS Inferred from the cDNA sequence of Ref.2.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Band 4.1-like protein 3 alternativeName: 4.1B alternativeName: Differentially expressed in adenocarcinoma of the lung protein 1 shortName: DAL-1 shortName: DAL1P shortName: mDAL-1 alternativeName: fullName evidence="10"Erythrocyte membrane protein band 4.1-like 3 component recommendedName: Band 4.1-like protein 3, N-terminally processed /component |
| geneName | Epb41l3 Dal1 Epb4.1l3 Kiaa0987 |
| identifier | Q9WV92 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Actin-binding Alternative splicing Apoptosis Cell junction Cell membrane Cytoplasm Cytoskeleton Membrane Phosphoprotein Reference proteome Tumor suppressor |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Epb41l3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | E41L3_MOUSE Q69ZT8 Q9R102 |
| sequenceLength | 929 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:146687] UniProt:Q9WV92-2 Epb41l3 [Mus musculus] [ReferenceIsoform:146688] UniProt:Q9WV92-3 Epb41l3 [Mus musculus] [ReferenceIsoform:146689] UniProt:Q9WV92-4 Epb41l3 [Mus musculus] [ReferenceIsoform:146690] UniProt:Q9WV92-5 Epb41l3 [Mus musculus] [ReferenceIsoform:146691] UniProt:Q9WV92-6 Epb41l3 [Mus musculus] [ReferenceIsoform:146692] UniProt:Q9WV92-7 Epb41l3 [Mus musculus] [ReferenceIsoform:227826] UniProt:Q9WV92-8 Epb41l3 [Mus musculus] [ReferenceIsoform:415871] UniProt:Q9WV92-1 Epb41l3 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9662959] Epb41l3 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9WV92 Epb41l3 (89582)
