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Details on Person 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Class:Id	BlackBoxEvent:8956184
_displayName	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
_doRelease	TRUE
_timestamp	2017-02-28 16:42:01
authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8956183] Rothfels, Karen, 2017-01-17
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input	[Complex:8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8956167] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 [LiteratureReference:8956157] Interaction of NUB1 with the proteasome subunit S5a [LiteratureReference:8956170] The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 [LiteratureReference:8956153] Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy [LiteratureReference:8956152] FAT10ylation as a signal for proteasomal degradation
modified	[InstanceEdit:8979130] Rothfels, Karen, 2017-02-21 [InstanceEdit:8980602] Rothfels, Karen, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
output	[Complex:68819] 26S proteasome [cytosol] [Homo sapiens] [DefinedSet:8956132] NUB1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome [Homo sapiens] [Reaction:8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes [Homo sapiens] [Reaction:8951644] Release of mature NEDD8 [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8956185] R-HSA-8956184.2
summation	[Summation:8956180] NUB1 mediates the 26S proteasome-dependent degradation of NE...
(hasEvent)	[Pathway:8951664] Neddylation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9767169] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates [NegativePrecedingEvent:9767188] Futile Cycle: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates [NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates [NegativePrecedingEvent:9767202] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
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