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Details on Person VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7

Class:Id	Reaction:8956099
_displayName	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
_doRelease	TRUE
_timestamp	2022-02-28 18:06:17
authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8956100] Rothfels, Karen, 2017-01-16
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input	[Complex:8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8956071] UBXN7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8956086] Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex [LiteratureReference:8955142] DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase [LiteratureReference:8955180] The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions [LiteratureReference:8956088] UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation [LiteratureReference:8956117] NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway [LiteratureReference:9755296] Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein [LiteratureReference:9755287] UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins
modified	[InstanceEdit:8956121] Rothfels, Karen, 2017-01-16 [InstanceEdit:8979160] Rothfels, Karen, 2017-02-21 [InstanceEdit:8980630] Rothfels, Karen, 2017-02-28 [InstanceEdit:9755293] Rothfels, Karen, 2021-10-07 [InstanceEdit:9758184] Rothfels, Karen, 2021-11-09 [InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 [InstanceEdit:9762223] Rothfels, Karen, 2022-01-18 [InstanceEdit:9766693] Rothfels, Karen, 2022-02-23 [InstanceEdit:9767173] Rothfels, Karen, 2022-02-25 [InstanceEdit:9767548] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
negativePrecedingEvent	[NegativePrecedingEvent:9767172] Futile Cycle: 26S proteasome degrades HIFalpha
output	[Complex:8956077] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex [Homo sapiens] [Reaction:8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex [Homo sapiens]
regulatedBy	[NegativeRegulation:9755289] Negative regulation by 'MUL1 dimer [mitochondrial outer membrane]'
regulationReference	[RegulationReference:9755285] Negative regulation by 'MUL1 dimer [mitochondrial outer membrane]' UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8956101] R-HSA-8956099.4
summation	[Summation:8956095] The best characterized CRL2 substrate binding F-box protein ...
(hasEvent)	[Pathway:8951664] Neddylation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775170] Update Tracker - [Reaction:8956099] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 - v80:[addLiteratureReference, addRegulator, modifyText]
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No pathways have been reviewed or authored by VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (8956099)