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Details on Person COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex

Class:Id	Reaction:8956045
_displayName	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
_doRelease	TRUE
_timestamp	2017-02-28 16:43:12
authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8956043] deNEDDylase activity of COP9 signalosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8956044] Rothfels, Karen, 2017-01-13
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input	[Complex:8952585] NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8956000] Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels [LiteratureReference:8956009] The COP9 signalosome regulates Skp2 levels and proliferation of human cells [LiteratureReference:8955981] Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability [LiteratureReference:8953197] F-box-directed CRL complex assembly and regulation by the CSN and CAND1 [LiteratureReference:8955995] Structural basis for a reciprocal regulation between SCF and CSN [LiteratureReference:8955463] CSN- and CAND1-dependent remodelling of the budding yeast SCF complex [LiteratureReference:8955437] CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire [LiteratureReference:8953261] The COP9 signalosome: more than a protease [LiteratureReference:8955979] Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers
modified	[InstanceEdit:8961958] Rothfels, Karen, 2017-02-06 [InstanceEdit:8979140] Rothfels, Karen, 2017-02-21 [InstanceEdit:8980612] Rothfels, Karen, 2017-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex
output	[EntityWithAccessionedSequence:8955926] NEDD8 [nucleoplasm] [Homo sapiens] [Complex:8955960] CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8952638] AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex [Homo sapiens] [Reaction:8952639] NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8956046] R-HSA-8956045.2
summation	[Summation:8979125] The COP9 signalosome (also known as CSN) is a highly conserv...
(hasEvent)	[Pathway:8951664] Neddylation [Homo sapiens]
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