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Details on Person Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin

Class:IdReaction:8955873
_displayNamePolyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin
_doReleaseTRUE
_timestamp2019-07-24 13:52:32
authored[InstanceEdit:8955880] D'Eustachio, Peter, 2017-01-13
catalystActivity[CatalystActivity:8955866] tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol]
catalystActivityReference[CatalystActivityReference:9643188] tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol] Tubulin polyglutamylase enzymes are members of the TTL domain protein family
compartment[Compartment:70101] cytosol
created[InstanceEdit:8955871] D'Eustachio, Peter, 2017-01-13
edited[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
goBiologicalProcess[GO_BiologicalProcess:2677] protein polyglutamylation
input[Complex:190599] Microtubule [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
isChimericTRUE
literatureReference[LiteratureReference:8866085] Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function
[LiteratureReference:8866060] Tubulin polyglutamylase enzymes are members of the TTL domain protein family
modified[InstanceEdit:8955879] D'Eustachio, Peter, 2017-01-13
[InstanceEdit:8956249] D'Eustachio, Peter, 2017-01-18
[InstanceEdit:9006067] Jupe, Steve, 2017-05-12
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9655243] D'Eustachio, Peter, 2019-07-23
[InstanceEdit:9655301] D'Eustachio, Peter, 2019-07-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePolyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin
output[Complex:8982725] Alpha-polyglutamylated microtubule [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
releaseDate2017-03-27
reviewed[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:8955877] R-NUL-8955873.5
summation[Summation:8955864] Polyglutamylase complex polyglutamylates alpha subunits of t...
(inferredFrom)[Reaction:8955869] Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777602] Update Tracker - [Reaction:8955873] Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin - v70:[add_removeInput, add_removeOutput]
[_UpdateTracker:9781155] Update Tracker - [Reaction:8955873] Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin - v61:[add_removeOutput]
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