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Details on Person PRODH2 oxidises HPRO to 1PYR-3OH-5COOH

Class:Id	Reaction:8955817
_displayName	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH
_doRelease	TRUE
_timestamp	2025-02-25 22:17:12
authored	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
catalystActivity	[CatalystActivity:8955819] proline dehydrogenase activity of PRODH2 [mitochondrial inner membrane]
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
crossReference	[DatabaseIdentifier:9929444] RHEA:52513
edited	[InstanceEdit:8955818] Jassal, Bijay, 2017-01-13
input	[SimpleEntity:6784215] HPRO [mitochondrial matrix] [SimpleEntity:113597] FAD [mitochondrial inner membrane]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
literatureReference	[LiteratureReference:6784230] Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria
modified	[InstanceEdit:8955828] Jassal, Bijay, 2017-01-13 [InstanceEdit:8959529] Jassal, Bijay, 2017-01-26 [InstanceEdit:8959641] Jassal, Bijay, 2017-01-30 [InstanceEdit:8959645] Jassal, Bijay, 2017-01-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	PRODH2 oxidises HPRO to 1PYR-3OH-5COOH a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
output	[SimpleEntity:164934] FADH2 [mitochondrial inner membrane] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:9929425] 1PYR-3OH-5COOH [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8955820] R-HSA-8955817.3
structureModified	[InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
summation	[Summation:8955829] HPRO (4-hydroxy-L-proline) is oxidized to 1PYR-3OH-5COOH (L-...
(hasEvent)	[Pathway:70688] Proline catabolism [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)	[Reaction:70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS [Homo sapiens] [Reaction:9929439] ALDH4A1 oxidizes 1PYR-3OH-5COOH [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939798] Update Tracker - [Reaction:8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - v92:[add_removeOutput, modifyText]
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