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Details on Person PGP:Mg2+ dimer hydrolyses G3P to glycerol

Class:IdReaction:8955794
_displayNamePGP:Mg2+ dimer hydrolyses G3P to glycerol
_doReleaseTRUE
_timestamp2025-02-26 19:30:52
authored[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
catalystActivity[CatalystActivity:8955800] sn-glycerol 3-phosphatase activity of PGP:Mg2+ dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9935658] glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol] Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes
compartment[Compartment:70101] cytosol
created[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
crossReference[DatabaseIdentifier:9935669] RHEA:66373
edited[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
goBiologicalProcess[GO_BiologicalProcess:15779] glycerol biosynthetic process
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:76114] G3P [cytosol]
internalReviewed[InstanceEdit:9937336] D'Eustachio, Peter, 2025-01-30
isChimericFALSE
literatureReference[LiteratureReference:9935672] Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress
[LiteratureReference:9935676] Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia
[LiteratureReference:8955768] Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes
[LiteratureReference:9935675] Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice
[LiteratureReference:9935673] Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities
modified[InstanceEdit:8955805] Jassal, Bijay, 2017-01-13
[InstanceEdit:8955806] Jassal, Bijay, 2017-01-13
[InstanceEdit:8959645] Jassal, Bijay, 2017-01-30
[InstanceEdit:9634602] D'Eustachio, Peter, 2019-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9935655] D'Eustachio, Peter, 2025-01-17
[InstanceEdit:9939403] D'Eustachio, Peter, 2025-02-26
namePGP:Mg2+ dimer hydrolyses G3P to glycerol
sn-glycerol 3-phosphate + H2O => glycerol + phosphate
output[SimpleEntity:76116] Glycerol [cytosol]
[SimpleEntity:29372] Pi [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2017-03-27
reviewed[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30
[InstanceEdit:9939401] Hill, David P, 2025-02-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8955801] R-HSA-8955794.4
structureModified[InstanceEdit:9935655] D'Eustachio, Peter, 2025-01-17
summation[Summation:8955799] Cytosolic PGP (Glycerol-3-phosphate phosphatase) catalyzes t...
(hasEvent)[Pathway:1483206] Glycerophospholipid biosynthesis [Homo sapiens]
[Pathway:8941514] Orphan 6 events [Homo sapiens]
(replacementInstances)[_Deleted:9935679] Deletion of instance: 8955775
(updatedInstance)[_UpdateTracker:9939843] Update Tracker - [Reaction:8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - v92:[add_removeInput, modifyText, removeLiteratureReference]
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