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Details on Person TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin

Class:Id	Reaction:8955706
_displayName	TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin
_doRelease	TRUE
_timestamp	2020-09-30 09:36:00
authored	[InstanceEdit:8955880] D'Eustachio, Peter, 2017-01-13
catalystActivity	[CatalystActivity:8955526] tubulin-tyrosine ligase activity of TTL [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8955710] D'Eustachio, Peter, 2017-01-12
edited	[InstanceEdit:8956248] Jupe, Steve, 2017-01-18
inferredFrom	[Reaction:8955724] TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin [Bos taurus]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29506] L-Tyr [cytosol] [Complex:8955574] detyr-alpha tubulin:beta tubulin [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8955565] Steady-state kinetic mechanism of bovine brain tubulin: tyrosine ligase [LiteratureReference:8955727] Structural basis of tubulin tyrosination by tubulin tyrosine ligase
modified	[InstanceEdit:8955740] D'Eustachio, Peter, 2017-01-12 [InstanceEdit:8956249] D'Eustachio, Peter, 2017-01-18 [InstanceEdit:8957282] Jupe, Steve, 2017-01-24 [InstanceEdit:9655243] D'Eustachio, Peter, 2019-07-23 [InstanceEdit:9655301] D'Eustachio, Peter, 2019-07-24 [InstanceEdit:9702336] Jassal, Bijay, 2020-09-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:8955726] alphaY-beta tubulin dimer [cytosol] [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8956247] Jassal, Bijay, 2017-01-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8955733] R-HSA-8955706.4
summation	[Summation:8955716] TTL (tubulin tyrosine ligase) ligates tyrosine (L-Tyr) to th...
(hasEvent)	[Pathway:8955332] Carboxyterminal post-translational modifications of tubulin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777632] Update Tracker - [Reaction:8955706] TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin - v70:[add_removeInput, add_removeOutput]
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