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Details on Person CAND1 binds cytosolic CRL E3 ubiquitin ligases

Class:Id	Reaction:8955241
_displayName	CAND1 binds cytosolic CRL E3 ubiquitin ligases
_doRelease	TRUE
_timestamp	2022-02-25 01:01:42
authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8955240] Rothfels, Karen, 2017-01-10
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
input	[EntityWithAccessionedSequence:5691146] CAND1 [cytosol] [Homo sapiens] [DefinedSet:8955222] CRL E3 ubiquitin ligases [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8955152] Function and regulation of cullin-RING ubiquitin ligases [LiteratureReference:8955166] RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis [LiteratureReference:5691158] CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex [LiteratureReference:208138] Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex [LiteratureReference:8953214] NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases [LiteratureReference:8955206] TIP120A associates with cullins and modulates ubiquitin ligase activity [LiteratureReference:5691186] Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases [LiteratureReference:8953197] F-box-directed CRL complex assembly and regulation by the CSN and CAND1 [LiteratureReference:8953164] Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins [LiteratureReference:8952201] Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation [LiteratureReference:8955154] Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation [LiteratureReference:8955158] Neddylation-induced conformational control regulates cullin RING ligase activity in vivo [LiteratureReference:8955437] CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire [LiteratureReference:8955463] CSN- and CAND1-dependent remodelling of the budding yeast SCF complex [LiteratureReference:8962059] Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8
modified	[InstanceEdit:8955481] Rothfels, Karen, 2017-01-11 [InstanceEdit:8961958] Rothfels, Karen, 2017-02-06 [InstanceEdit:8962066] Rothfels, Karen, 2017-02-07 [InstanceEdit:8979136] Rothfels, Karen, 2017-02-21 [InstanceEdit:8980608] Rothfels, Karen, 2017-02-28 [InstanceEdit:9767176] Rothfels, Karen, 2022-02-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CAND1 binds cytosolic CRL E3 ubiquitin ligases
negativePrecedingEvent	[NegativePrecedingEvent:9767177] Futile Cycle: COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
output	[Complex:8955224] CRL E3 ubiquitin ligase:CAND1 [cytosol] [Homo sapiens]
releaseDate	2017-03-27
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8955242] R-HSA-8955241.3
summation	[Summation:8955238] CRL complexes consist of a cullin protein (CUL1, 2, 3, 4A, 4...
(hasEvent)	[Pathway:8951664] Neddylation [Homo sapiens]
(precedingEvent)	[Reaction:8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes [Homo sapiens]
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