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Details on Person NADK2 dimer phosphorylates NAD+ to NADP+

Class:Id	Reaction:8955030
_displayName	NADK2 dimer phosphorylates NAD+ to NADP+
_doRelease	TRUE
_timestamp	2025-02-11 17:23:21
authored	[InstanceEdit:8955029] Jassal, Bijay, 2017-01-10
catalystActivity	[CatalystActivity:8955033] NAD+ kinase activity of NADK2 dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:8955029] Jassal, Bijay, 2017-01-10
crossReference	[DatabaseIdentifier:9938170] RHEA:18630
edited	[InstanceEdit:8955029] Jassal, Bijay, 2017-01-10
input	[SimpleEntity:113526] NAD+ [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix]
internalReviewed	[InstanceEdit:9938268] D'Eustachio, Peter, 2025-02-11
isChimeric	FALSE
literatureReference	[LiteratureReference:8955032] Identification and characterization of a human mitochondrial NAD kinase [LiteratureReference:8955042] Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia
modified	[InstanceEdit:8955036] Jassal, Bijay, 2017-01-10 [InstanceEdit:8955045] Jassal, Bijay, 2017-01-10 [InstanceEdit:8955386] Jassal, Bijay, 2017-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10 [InstanceEdit:9938269] D'Eustachio, Peter, 2025-02-11
name	NADK2 dimer phosphorylates NAD+ to NADP+ NAD(+) + ATP => ADP + NADP(+) + H(+)
output	[SimpleEntity:113563] NADP+ [mitochondrial matrix] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:9938195] SLC25A51 mediates mitochondrial uptake of NAD+ [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2017-03-27
reviewed	[InstanceEdit:8955387] D'Eustachio, Peter, 2017-01-11
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8955034] R-HSA-8955030.3
structureModified	[InstanceEdit:9938178] D'Eustachio, Peter, 2025-02-10
summation	[Summation:8955046] NAD kinase is the sole NADP(+) biosynthetic enzyme. A cytoso...
(hasEvent)	[Pathway:196807] Nicotinate metabolism [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
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No pathways have been reviewed or authored by NADK2 dimer phosphorylates NAD+ to NADP+ (8955030)